Synthesis, Spectroscopic and Antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (E)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide)

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Fasina, T.M.
Dueke-Eze, C.U.
Idika, F.N.
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Journal of Applied Sciences and Environmental Management
The objective of this study is to investigate the antimicrobial activity of novel Schiff base metal complexes. The resistance of micro-organisms to classical antimicrobial compounds poses a challenge to effective management and treatment of some diseases. In line with this, copper (II), nickel (II) and cobalt (II) complexes of the Schiff base ligand (E)-N’-(2- hydroxy-5-nitrobenzylidene) isonicotinohydrazide) were synthesized and characterized based on elemental analysis, conductivity measurements, infrared and electronic absorption spectroscopy. The results suggest a 1:2 [M:L] stoichiometry for the copper and cobalt complexes and a 1:1 [M:L] ratio for the nickel complex. The electronic absorption spectral data support octahedral geometry for cobalt(II) and copper(II) complexes and square planar for nickel (II). In-vitro antimicrobial properties of the compounds evaluated against five pathogenic bacteria using the agar-well diffusion method revealed that the activity was in the order Ni>Co>Cu. These compounds can be used as substrates for development of new antimicrobial agents.
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Research Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry::Coordination chemistry , isonicotinohydrazide , Schiff base metal complexes , antimicrobial activity , In-vitro , electronic spectra
Fasina, T. M., Dueke-Eze, C. U., & Idika, F. N. (2017). Synthesis, spectroscopic and antimicrobial properties of Co (II), Ni (II) and Cu (II) complexes of (E)-N’-(2-hydroxy-5-nitrobenzylidene) isonicotinohydrazide. Journal of Applied Sciences and Environmental Management, Vol.21(1), 120-125.