Synthesis, Spectroscopic and Antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (E)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide)

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dc.contributor.authorFasina, T.M.
dc.contributor.authorDueke-Eze, C.U.
dc.contributor.authorIdika, F.N.
dc.date.accessioned2019-09-06T08:03:32Z
dc.date.available2019-09-06T08:03:32Z
dc.date.issued2017-02
dc.descriptionStaff publicationen_US
dc.description.abstractThe objective of this study is to investigate the antimicrobial activity of novel Schiff base metal complexes. The resistance of micro-organisms to classical antimicrobial compounds poses a challenge to effective management and treatment of some diseases. In line with this, copper (II), nickel (II) and cobalt (II) complexes of the Schiff base ligand (E)-N’-(2- hydroxy-5-nitrobenzylidene) isonicotinohydrazide) were synthesized and characterized based on elemental analysis, conductivity measurements, infrared and electronic absorption spectroscopy. The results suggest a 1:2 [M:L] stoichiometry for the copper and cobalt complexes and a 1:1 [M:L] ratio for the nickel complex. The electronic absorption spectral data support octahedral geometry for cobalt(II) and copper(II) complexes and square planar for nickel (II). In-vitro antimicrobial properties of the compounds evaluated against five pathogenic bacteria using the agar-well diffusion method revealed that the activity was in the order Ni>Co>Cu. These compounds can be used as substrates for development of new antimicrobial agents.en_US
dc.identifier.citationFasina, T. M., Dueke-Eze, C. U., & Idika, F. N. (2017). Synthesis, spectroscopic and antimicrobial properties of Co (II), Ni (II) and Cu (II) complexes of (E)-N’-(2-hydroxy-5-nitrobenzylidene) isonicotinohydrazide. Journal of Applied Sciences and Environmental Management, Vol.21(1), 120-125.en_US
dc.identifier.issn1119-8362
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5368
dc.language.isoenen_US
dc.publisherJournal of Applied Sciences and Environmental Managementen_US
dc.relation.ispartofseriesJournal of Applied Sciences and Environmental Management;Vol.21(1)
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry::Coordination chemistryen_US
dc.subjectisonicotinohydrazideen_US
dc.subjectSchiff base metal complexesen_US
dc.subjectantimicrobial activityen_US
dc.subjectIn-vitroen_US
dc.subjectelectronic spectraen_US
dc.titleSynthesis, Spectroscopic and Antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (E)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide)en_US
dc.typeArticleen_US
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