Dissolution mechanism of tablets produced from coated lactose powder
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The use of the equation of Kitazawa et aJ in the analysis of the dissolution process of tablets produced from lactose powder coated with paraffin has suggested either an initial breaking of the tablets into particles that subsequently break down into smaller particles or a progressive breaking of the tablet into smaller particles. The former produces a change in rate constant from k1 to k2. Diluents (for example, lactose) included in the formulation of low dose potent drugs provide the main bulk of a tablet and play a significant role in the release of the drug substance (Wagner 1971). The wettability of the tablet surface also influences its disintegration and dissolution and subsequent release of the active ingredient. This report deals with the probable mechanisms involved in the dissolution of tablets produced from lactose powder coated with paraffins.
Equation of Kitazawa , Lactose powder , Dissolution process of tablets , Particles , Research Subject Categories::PHARMACY
Igwilo, C.I. & Pilpel, N. (1987). Dissolution mechanism of tablets produced from coated lactose powder. J.Pharm.Pharmacol, 39, 301-302.