Dissolution mechanism of tablets produced from coated lactose powder

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dc.contributor.authorIgwilo, C.I.
dc.contributor.authorPilpel, N.
dc.date.accessioned2020-03-02T14:53:28Z
dc.date.available2020-03-02T14:53:28Z
dc.date.issued1987
dc.descriptionStaff publicationsen_US
dc.description.abstractThe use of the equation of Kitazawa et aJ in the analysis of the dissolution process of tablets produced from lactose powder coated with paraffin has suggested either an initial breaking of the tablets into particles that subsequently break down into smaller particles or a progressive breaking of the tablet into smaller particles. The former produces a change in rate constant from k1 to k2. Diluents (for example, lactose) included in the formulation of low dose potent drugs provide the main bulk of a tablet and play a significant role in the release of the drug substance (Wagner 1971). The wettability of the tablet surface also influences its disintegration and dissolution and subsequent release of the active ingredient. This report deals with the probable mechanisms involved in the dissolution of tablets produced from lactose powder coated with paraffins.en_US
dc.identifier.citationIgwilo, C.I. & Pilpel, N. (1987). Dissolution mechanism of tablets produced from coated lactose powder. J.Pharm.Pharmacol, 39, 301-302.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7986
dc.language.isoenen_US
dc.relation.ispartofseriesJ.Pharm.Pharmacol;Vol.39
dc.subjectEquation of Kitazawaen_US
dc.subjectLactose powderen_US
dc.subjectDissolution process of tabletsen_US
dc.subjectParticlesen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleDissolution mechanism of tablets produced from coated lactose powderen_US
dc.typeArticleen_US
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