Effects of administration of sertraline, clozapine, amitriptyline and imipramine on brain serotonin, liver enzymes and blood chemistry of rabbit
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Date
2009
Authors
Ebuehi, O.A.T.
Ikanone, CE
Balogun, AA
Akinwande, AI
Famuyiwa, OO
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Publisher
International Journal of Biological Chemical Sciences
Abstract
The chronic administration of sertraline, clozapine, amitriptyline and imipramine on brain serotonin, liver enzymes and blood chemistry of rabbits were investigated. Sixty rabbits were equally divided into 5 groups and each group was intraperitoneally administered 2 ml of 0.5 mg of the respective drug/kg body weight/day) and saline as control for 28 days. After 28 days, the rabbits were sacrificed; blood taken, liver and brain were excised. The concentration of total protein, serotonin, cholesterol and triglyceride in serum, liver and brain were determined. The activities of serum and liver alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase were also assayed. The serum serotonin and brain serotonin levels in rabbits administered the respective drugs were significantly (p<0.01) higher than in rabbits administered saline. Brain protein and cholesterol levels in rabbit administered saline were significantly lower than in those administered sertraline, clozapine, amitriptyline and imipramine, with no difference in the serum protein levels. The activities of serum and liver AST and ALT of rabbits administered saline were significantly lower than in those administered the respective drugs, with the exception of serum ALP. Data from the study indicate that intraperitoneal administration of imipramine or amitriptyline produced a more pronounced effect on brain serotonin, activities of liver derived enzymes in serum and blood chemistry of rabbits compared to sertraline or clozapine.
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Citation
Ebuehi, O.A.T., Ikanone, CE, Balogun AA, Akinwande AI, and Famuyiwa OO (2009). Effects of administration of sertralin, clozapine, amitriptyline and imipramine on the brain serotonin, liver enzymes and blood chemistry of rabbits. International Journal of Biological Chemical Sciences, 3(1): 85-94