Resistance patterns of streptococcus pneumoniae isolated from the upper respiratory tract of persons attending various clinics of a university teaching hospital in lagos
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Date
2006
Authors
Oduyebo, O.O.
Nwaka, D.U.
Nwaowolo, C.
Ogunsola, F.T.
Journal Title
Journal ISSN
Volume Title
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Abstract
The upper respiratory carriage rate, serotypes and resistance patterns or Streptococcus pneumoniae in persons attending four clinics of lhe Lagos University Teaching hospital (LUTH) were determined. Nasal swab specimens were collected room a total of 372 persons. J 7.!'i of whom were males and 177 were fe,nales. Their ages ranged from 14 weeks to 65 years. The upper respiratory carriage rate round in the total population or both adults ;ind children was 9.9°/o, bul the rate was hi5:hesl i11 children less lhan !\ years (18.6"/e). Among the 17 isolates that were available ror serotyping. there was no si&nificant serotype. though resistant serotypes like 2JF. 19F. 6A and 14 were identified. Initial oxacillin screening for penicillin resistance revealed that 12 out of J6 isolates were clearly sensitive, but combined with the result uf Etest. penicillin resistance was found to be 6.8°/o. Susceptibility testing by disc diffusion revealed that 80.S0/o of isolates were sensitive to ceftriaxone and 9 ... 4°/o to chloramphenicol. Sixty one percent were sensilive to crythromycin while 94.4°/• were resistant to co-trimoxazoJe and 80.S 0/. to tetracycline. Except for amoxicillin and cefotaxime which showed high activity, sensitivity pattern by [test was round to be similar to that of disc diffusion. The rnult of this study makH it possible to form ulate hypothesis for a larger study. In this study. the carriage rate or S. pneumoniae probably ranged rrom 2.6•/. to over 18.6•1. dtpenlling on the study population. If the limitations or this study are excluded in II larier study, the rate most likely will be higher. Also, ptnicillin resistance in carriuge strains would be up to 6.8°!., probably bightr, but may be intermediate. so penicillin could still be useful for treatment of pneumonia and probably otieis media, bul not mtttin&itis. There is reason to watch out for increased resistance to penicillin, cephaloporia and crythromycin. f\otost pneumoccal isolates would likely be resistant to tetracycline and cotrimoxazole.
Description
Staff publications
Keywords
Respiratory system , Streptococcus pneumoniae , Lagos University Teaching Hospital , Patients , Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Citation
Oduyebo, O.O, Nwaka, D.U, Nwawolo, C. and Ogunsola, F.T. (2006). Resistance patterns of Streptococcus pneumoniae isolated from the upper respiratory tract of persons attending various clinics of a University Teaching Hospital in Lagos, Nigeria - a preliminary study. African Journal of Clinical and Experimental Microbiology. 7: 89-97.
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https://ir.unilag.edu.ng/handle/123456789/7262
https://ir.unilag.edu.ng/handle/123456789/7262