Acute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomes

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dc.contributor.authorOshomah-Bello, E.
dc.contributor.authorEsezobor, C.I.
dc.contributor.authorSolarin, A.U.
dc.contributor.authorNjokanma, F.
dc.date.accessioned2020-02-11T14:00:24Z
dc.date.available2020-02-11T14:00:24Z
dc.date.issued2019
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: The prevalence of acute kidney injury (AKI) in children with severe malaria in sub- Saharan African may have been underestimated. The study aimed to determine the prevalence of AKI in children with severe malaria and its association with adverse hospital outcomes. Methods: At presentation, we measured complete blood count, serum bilirubin, and serum electrolytes, urea and creatinine in children with severe malaria. At 24 h after hospitalization, we repeated serum creatinine measurement. Urine passed in the first 24 h of hospitalization was also measured. We defined AKI and its severity using the Kidney Disease: Improving Global Outcome AKI guidelines. Results: The study involved 244 children (53.3% males) with a median age of 3.5 (1.9–7.0) years. One hundred and forty-four (59%) children had AKI, and it reached maximum Stages 1, 2 and 3 in 56 (23%), 45 (18.4%) and 43 (17.6%) children, respectively. The majority (86.1%) with AKI had only elevated serum creatinine. Mortality increased with increasing severity of AKI on univariate analysis but weakened on multiple logistic regression. Mortality was also higher in those with both oliguria and elevated serum creatinine than in those with elevated serum creatinine only (50% vs. 4.8%, p<0.001). Furthermore, children with AKI spent three days more in hospital than those without AKI (p<0.001). Conclusions: Acute kidney injury complicates severe malaria in 6 out of every 10 children and is commonly identified using elevated serum creatinine. It is also associated with adverse hospital outcome.en_US
dc.identifier.citationOshomah-Bello, E.O.; Esezobor C.I.; Solarin A.U.; Njokanma F.O. (2019). Acute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomes. J Trop Pediatr. doi: 10.1093/tropej/fmz057.en_US
dc.identifier.otherdoi: 10.1093/tropej/fmz057
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7632
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectacute kidney injuryen_US
dc.subjectchildrenen_US
dc.subjectKDIGO AKI guidelineen_US
dc.subjectmalariaen_US
dc.subjectmortalityen_US
dc.subjectSub-Saharan Africaen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleAcute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomesen_US
dc.typeArticleen_US
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