Contributions of fluoride to the sensitivity of oral isolates to some anti-microbial agents

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Mendie, U.E.
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African Journal Online(Nigerian Dental Journal)
Objective: Plaque formation on teeth surfaces, gingivitis, and caries has been associated with the presence and activities of oral flora; and several agents have been demonstrated to exhibit anti-plaque potentials. This study is designed to evaluate the inhibitory potentials of some agents on fluoride-exposed and non-exposed oral isolates capable of causing dental plaque and infections. Method: Agar dilution method was used to determine the Minimum Inhibitory Concentration (MIC) of triclosan, ampicillin, and chlorhexidine against fluoride-exposed and non-exposed Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Bacillus subtilis, and Candida albicans. Results: All the agents showed remarkable antimicrobial activities against fluoride-exposed oral isolates. Our study also showed a 75% decrease (p<0.05) in the MICs of all the agents used against the test organisms after 4 weeks of exposure to 0.11w/w% fluoride. In contrast, the MIC of the non-exposed isolates were significantly higher(p<0.05) and did not change throughout this period. Triclosan and chlorhexidine showed, in addition to their antibacterial activities, outstanding antifungal action resulting in a more than 93% increase in the susceptibility of Candida albicans. These observations may be attributable to the synergistic effect of fluoride on the antimicrobial activity of these agents. Conclusion: It can be inferred from this study that regular daily use of fluoride-containing dentifrice having antimicrobial agents such as triclosan or in conjunction with mouthwash containing chlorhexidine will aid in the prevention of plaque formation.
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Fluoride, oral isolates, antimicrobial, Minimum Inhibitory Concentration , Fluoride , oral isolates , antimicrobial , Minimum Inhibitory Concentration , Research Subject Categories::PHARMACY
Mendie, U. E. (2007). Contributions of fluoride to the sensitivity of oral isolates to some anti-microbial agents. Nigerian Dental Journal, 15(1), 9-12.