Contributions of fluoride to the sensitivity of oral isolates to some anti-microbial agents
dc.contributor.author | Mendie, U.E. | |
dc.date.accessioned | 2022-09-09T14:24:59Z | |
dc.date.available | 2022-09-09T14:24:59Z | |
dc.date.issued | 2007 | |
dc.description | Scholarly article | en_US |
dc.description.abstract | Objective: Plaque formation on teeth surfaces, gingivitis, and caries has been associated with the presence and activities of oral flora; and several agents have been demonstrated to exhibit anti-plaque potentials. This study is designed to evaluate the inhibitory potentials of some agents on fluoride-exposed and non-exposed oral isolates capable of causing dental plaque and infections. Method: Agar dilution method was used to determine the Minimum Inhibitory Concentration (MIC) of triclosan, ampicillin, and chlorhexidine against fluoride-exposed and non-exposed Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Bacillus subtilis, and Candida albicans. Results: All the agents showed remarkable antimicrobial activities against fluoride-exposed oral isolates. Our study also showed a 75% decrease (p<0.05) in the MICs of all the agents used against the test organisms after 4 weeks of exposure to 0.11w/w% fluoride. In contrast, the MIC of the non-exposed isolates were significantly higher(p<0.05) and did not change throughout this period. Triclosan and chlorhexidine showed, in addition to their antibacterial activities, outstanding antifungal action resulting in a more than 93% increase in the susceptibility of Candida albicans. These observations may be attributable to the synergistic effect of fluoride on the antimicrobial activity of these agents. Conclusion: It can be inferred from this study that regular daily use of fluoride-containing dentifrice having antimicrobial agents such as triclosan or in conjunction with mouthwash containing chlorhexidine will aid in the prevention of plaque formation. | en_US |
dc.identifier.citation | Mendie, U. E. (2007). Contributions of fluoride to the sensitivity of oral isolates to some anti-microbial agents. Nigerian Dental Journal, 15(1), 9-12. | en_US |
dc.identifier.issn | 0189-1006 | |
dc.identifier.other | DOI: 10.4314/ndj.v15i1.42094 | |
dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/11396 | |
dc.language.iso | en | en_US |
dc.publisher | African Journal Online(Nigerian Dental Journal) | en_US |
dc.subject | Fluoride, oral isolates, antimicrobial, Minimum Inhibitory Concentration | en_US |
dc.subject | Fluoride | en_US |
dc.subject | oral isolates | en_US |
dc.subject | antimicrobial | en_US |
dc.subject | Minimum Inhibitory Concentration | en_US |
dc.subject | Research Subject Categories::PHARMACY | en_US |
dc.title | Contributions of fluoride to the sensitivity of oral isolates to some anti-microbial agents | en_US |
dc.type | Article | en_US |
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