Toxicological evaluation of the stem bark of Burkea africana Hook. (Caesalpiniaceae) in Wistar rats

Simple item page
dc.contributor.authorEboji, O.K
dc.contributor.authorSowemimo, A.A
dc.contributor.authorOgunkunle, O.O
dc.contributor.authorSofidiya, M.O
dc.contributor.authorBadmos, K.B
dc.contributor.authorAbdulkareem, F.B
dc.date.accessioned2021-04-27T11:19:57Z
dc.date.available2021-04-27T11:19:57Z
dc.date.issued2019
dc.descriptionScholarly articlesen_US
dc.description.abstractBurkea africana Hook. (Caesalpiniaceae) is used traditionally to treat ulcers, headaches, skin disease and tumors. The study investigated the acute, sub-acute and chronic toxicity profiles of the ethanolic extract of Burkea africana stem bark. Rats of either sexes were used in this study (n=10). For acute toxicity, a single dose of 5,000 mg/kg was administered while for the sub-acute and chronic toxicity study, three doses (40, 200 and 1000 mg/kg) of the extract were administered orally for 28 and 90 days respectively. At the end of each study, the biochemical, hematological and histological parameters were evaluated. No mortality or behavioral changes were observed in the acute toxicity study. Extract caused significant changes in the hematological parameters after the sub-acute toxicity study. In the chronic toxicity study, the extract caused significant increase in the white blood cell count of the 200 mg/kg group. There was significant increase in the platelet count of treated groups compared to control in the sub-acute and chronic toxicity studies, with an observed total mortality of all the animals in the 1000 mg/kg group on the 44th day. No adverse pathology was observed in the organs examined. The extract elicited a hematological response and short term consumption of the extract at low doses might be relatively safe. However, long term consumption at high doses should be discouraged.en_US
dc.identifier.citationEboji O. K., Sowemimo A. A., Ogunkunle O. O., Sofidiya M. O., Badmos K. B., Abdulkareem F. B. (2019). Toxicological evaluation of the stem bark of Burkea africana Hook. (Caesalpiniaceae) in Wistar rats. Nigerian Journal Natural Products and Medicine 23, 33-40.en_US
dc.identifier.issn1118-6267
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9373
dc.language.isoenen_US
dc.publisherThe Nigerian Society of Pharmacognosyen_US
dc.relation.ispartofseriesNigerian Journal Natural Products and Medicine;23
dc.subjectBurkea africanaen_US
dc.subjectRaten_US
dc.subjectToxicityen_US
dc.subjectUlceren_US
dc.subjectHematologyen_US
dc.subjectSerum biochemistryen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.titleToxicological evaluation of the stem bark of Burkea africana Hook. (Caesalpiniaceae) in Wistar ratsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
32. Burkea and toxicity 2019.pdf
Size:
197.59 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Pharmacognosy- Scholarly Publications