T-cell deplete versus T-cell replete haploidentical hematopoietic stem cell transplantation for sickle cell disease: where are we?.

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dc.contributor.authorPatel, D.A.
dc.contributor.authorAkinsete, A.M.
dc.contributor.authorConnelly, J.A.
dc.contributor.authorKassim, A.A.
dc.date.accessioned2019-12-09T14:18:02Z
dc.date.available2019-12-09T14:18:02Z
dc.date.issued2019-09-12
dc.descriptionStaff publicationsen_US
dc.description.abstractIntroduction: Severe sickle cell disease is associated with progressive end-organ damage and early mortality in adults. While allogeneic hematopoietic cell transplant from a matched related donor is curative, the vast majority of patients do not have a compatible sibling. Accordingly, platforms using haploidentical donors have been developed, which provide near-universal availability. Areas covered: This review focuses on the two commonly used approaches for haploidentical hematopoietic transplants, namely T-cell deplete and T-cell replete, each of which is associated with unique benefits and drawbacks. The purpose of this paper is to facilitate individualized decision-making for patients and providers by reviewing the pros- and cons of these differing approaches. Expert opinion: Individuals with sickle cell disease eligible for a hematopoietic cell transplant can be considered based on recent results. Comparable outcomes are seen with T-cell deplete and T-cell replete approaches. The choice depends largely on institutional preferenceen_US
dc.identifier.citationPatel, D.A, Akinsete, A.M, Connelly, J.A., Kassim, A.A. T-cell deplete versus T-cell replete haploidentical hematopoietic stem cell transplantation for sickle cell disease: where are we?. Expert Rev Hematol. 2019 Sep;12(9):733-752.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7053
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSIEVER INCen_US
dc.relation.ispartofseriesExpert Rev Hematol.;Vol.12(9)
dc.subjectHaploidenticalen_US
dc.subjectMortalityen_US
dc.subjectallogeneic hematopoietic cell transplanten_US
dc.subjectSickle cell diseaseen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleT-cell deplete versus T-cell replete haploidentical hematopoietic stem cell transplantation for sickle cell disease: where are we?.en_US
dc.typeArticleen_US
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