Effects of ethanolic extract of Tetrapleura tetraptera on liver function profile and histopathology in male Dutch white rabbits.

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dc.contributor.authorOdesanmi, S.O
dc.contributor.authorLawal, R.A
dc.contributor.authorOjokuku, S.A
dc.date.accessioned2019-09-16T11:23:41Z
dc.date.available2019-09-16T11:23:41Z
dc.date.issued2009
dc.description.abstractTetrapleura tetraptera fruit has wide use in the South East and Western Nigeria as a spice as well as a plant to treat various medical ailments. It has been reported that feeding of extracts to animals produced some toxic effects and pathological lesions in some organs. This study was designed to investigate the hepatotoxic effects of 10 days of oral administration of ethanolic extract of Tetrapleura tetraptera extract (TTE) in mature male rabbits. Twenty healthy acclimatized male rabbits (1.4-1.6 kg body weight) were randomly assigned to 4 groups. Animals in group 1 served as the control and received only water and no extract. Animals in groups 2-4 were administered 50, 100 and 150 mg kg-1 bodyweight of TTE. All animals were fasted for 18 h after withdrawal of treatment and sacrificed after anaesthesia. Venous blood sample of groups were analysed for liver function parameters. Histopathological examination of internal organs was also carried out. TTE caused elevation in serum AST and alteration of various metabolic parameters and did not induce any marked pathological lesions in the liver.en_US
dc.identifier.citationSO Odesanmi, RA Lawal, SA Ojokuku International Journal of Tropical Medicine 4 (4), 136-139en_US
dc.identifier.issn1816-3319
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5540
dc.language.isoenen_US
dc.publisherMedwell Onlineen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectTetrapleura tetrapteraen_US
dc.subjectHepatoxicityen_US
dc.subjectDutch-whiteen_US
dc.subjectHistopathologyen_US
dc.subjectLiveren_US
dc.subjectPhytochemicalen_US
dc.titleEffects of ethanolic extract of Tetrapleura tetraptera on liver function profile and histopathology in male Dutch white rabbits.en_US
dc.typeArticleen_US
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