Antiplasmodial Activity of Methanolic Extract of Asparagus officinalis L. Stem on Plasmodium berghei infected mice

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dc.contributor.authorMinari, J. B.
dc.contributor.authorOdutuga, A. A.
dc.contributor.authorBamisaye, F. A.
dc.contributor.authorBabatola, L. J.
dc.date.accessioned2019-08-24T03:15:51Z
dc.date.available2019-08-24T03:15:51Z
dc.date.issued2016
dc.description.abstractThis study aims at investigating the antiplasmodial activity of rnethauolic extract of Asparagus officinalis L. stem on Plasmodium berghei infected mice. To investigate this, the mice were infected with Pberghei to cause malaria. The mice were simultaneously given oral doses (20, 40 and 60 mg/kg body weight) of methanolic extract of A. officina/is L. stem. The phytochemical constituents of the extract revealed the presence of alkaloids, phenolics, cardiacĀ· glycosides, flavonoids, terpenoid and steroid. The extract administered to the infected mice significantly suppressed the parasite. The extract also significantly (P<0.05) reduced the activities of serum aspatate aminotransferase (AST), alkaline phosphate (ALP), alanine aminotransferase (ALT). While blood corpuscles (WBC), red blood corpuscles (RBC), haemoglobin (HOB), packed cell volume (PCV), platelets (PLT) and the mean corpuscular hemoglobin concentration (MCHC) showed significant (P<0.05) increase after the administration of the extracrwhile mean corpuscular volume (MCY).and the mean corpuscular hemoglobin (MCH) showed significant (P<0.05) reduction. Present findings suggests that the plant extract contains phytochemicals that have antiplasmodial and hepatoprotective properties.en_US
dc.identifier.citationMinari, J. B., Odutuga, A. A., Bamisaye, F. A., Babatola, L. J. Antiplasmodial Activity of Methanolic Extract of Asparagus officinalis L. Stem on Plasmodium berghei infected mice. Pakistan Journal of Scientific and Industrial Research. Series B. Biological Sciences; 59(2); p. 99-104en_US
dc.identifier.issn2221-6421
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4667
dc.language.isoenen_US
dc.publisherPakistan Journal of Scientific and Industrial Research.en_US
dc.subjectantiplasmodial activity, Asparagus officinalis, Plasmodium berghei, phytochemicalsen_US
dc.titleAntiplasmodial Activity of Methanolic Extract of Asparagus officinalis L. Stem on Plasmodium berghei infected miceen_US
dc.typeArticleen_US
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