Effects of molecular coatings on the compression and tableting of some pharmaceutical powders
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lnternational Journal of Pharmaceutics
Coating the particles of various pharmaceutical powders with up to 10 molecular layers of paraffins, fatty acids, surfactants, silicones and polymers noticeably alters their mechanical behaviour when they are compressed into beds or formed into tablets. At low packing fractions of 0.41 the tensile strengths of the beds tend to increase, then decrease and then increase again with increasing coating concentration. At higher packing fractions of 0.82 the tensile strengths of tablets generally decrease with coating concentration and there is an inverse relationship between their tensile strength and the ratio of the elasticity to the compression of the coated powders.
Powder , Molecular coating , Compression , Tableting , Tensile strength , Plasto-elastic properties , Research Subject Categories::PHARMACY
Pilpel, N., Igwilo, C.I. and Malamataris, S. (1991). Effects of molecular coatings on the compression and tableting of some pharmaceutical powders. International Journal of Pharmaceutics, 68, 157-166