Occult Hepatitis B Virus Infection among Sickle Cell Anaemia Subjects in Lagos, Nigeria

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dc.contributor.authorBadiru, M.A
dc.contributor.authorAkinbami, A.A
dc.contributor.authorUche, E.I
dc.contributor.authorIbrahim, I.N
dc.contributor.authorBamiro, R.A
dc.contributor.authorAdelekan, O.O
dc.contributor.authorBenjamin, A
dc.contributor.authorSuleiman, A.M
dc.contributor.authorOgbenna, A.A
dc.contributor.authorAdeyemi, I.O
dc.contributor.authorAnaduaka, C.D
dc.date.accessioned2022-09-14T09:27:01Z
dc.date.available2022-09-14T09:27:01Z
dc.date.issued2021
dc.descriptionScholarly articleen_US
dc.description.abstractObjective: Hepatitis B virus (HBV) infection remains a major public health problem worldwide. HBV is one of the transfusion transmissible infections. Occult HVB infection (OBI) is the presence of HBV DNA in blood or liver tissue in hepatitis B surface antigen (HBsAg) sero-negative subjects. Thus the absence of HBsAg in the blood is inadequate to determine the presence of occult HBV infections. This study aimed to determine the seroprevalence of occult HBV infection among sickle cell anaemia (HbSS) subjects in Lagos, Nigeria. Methods: This was a cross sectional study among 100 consenting adults HbSS patients attending the Haematology out-patient clinic at the Lagos State University Teaching Hospital, Ikeja (LASUTH). All participants were screened for HbSAg using SD Biolin HbSAG rapid kit and those with negative results had HBV DNA polymerase chain reaction (PCR). Data were analysed by statistical package for social science (SPSS) version 23, p≤0.05 was considered significant. Results: The prevalence of occult HBV infection among HbSS participants was 1%, consisting of 1% prevalence for the surface antigen and 0% prevalence of pre-core and core antigens of the HBV DNA. Conclusion: The low prevalence (1%) of occult HBV seen in our study shows that it may not be cost-effective to routinely screen HbSS subjects for occult HBV infection using PCR.en_US
dc.identifier.citationBadiru, M. A., Akinbami, A. .,A Uche, E. I., Ibrahim, I. N., Bamiro, R. A., Adelekan, O. O., Benjamin, A., Suleiman, A. M., Ogbenna, A. A., Adeyemi, I. O. and Anaduaka, C. D. (2021). Occult Hepatitis B Virus Infection among Sickle Cell Anaemia Subjects in Lagos, Nigeria. LASU Journal of Medical Sciences. 6(2); 1-5en_US
dc.identifier.issn2672 - 5193
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11478
dc.language.isoenen_US
dc.publisherLASU Journal of Medical Sciencesen_US
dc.subjectHbSS,en_US
dc.subjectHBsAg,en_US
dc.subjectHBV DNAen_US
dc.subjectDNAen_US
dc.subjectPCRen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleOccult Hepatitis B Virus Infection among Sickle Cell Anaemia Subjects in Lagos, Nigeriaen_US
dc.typeArticleen_US
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