Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats
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Date
2018
Authors
okafor, IA
Gbotolorun, SC
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Background: Several studies have demonstrated Cisplatin-induced toxicity on the ovary. However, there
is a dearth of literature on the effect of Cisplatin on the non-gravid uterus.
Objective: This study investigated the effect of cisplatin and supplementation with Resveratrol on the
oxidant status and histoarchitecture of the uterus in Sprague-Dawley rats.
Materials and methods: Forty-five female Sprague–Dawley rats with average weight of 160 g divided into
9 groups (n = 5) were used in this study. Group 1 served as control and received distilled water. Groups 2
and 9 received cisplatin only. Groups 3, 4 and 5 received different doses (5, 10 and 20 mg/kg respectively)
of Resveratrol after a single dose of cisplatin. Groups 6, 7 and 8 received different doses (5, 10 and 20 mg/
kg respectively) of Resveratrol before cisplatin. At sacrifice, the uterus was analysed for relative organ
weight, histopathology and oxidation parameters.
Result: No significant difference was observed in Glutathione (GSH), Superoxide dismutase (SOD) and
Catalase (CAT) levels of rats treated with cisplatin and/or Resveratrol when compared to the control
group (p < .05). Compared with the control group, Cisplatin treated groups showed a significant increase
in Malondialdehyde (MDA) levels (p = .007 and .012) while groups treated with 20 mg/kg Resveratrol
before cisplatin showed a significant decrease (p = .003) in their MDA levels. Cisplatin and Resveratrol
treated groups showed normal histoarchitecture of the uterus.
Conclusion: This study showed that cisplatin-induced oxidative stress can be prevented by supplementation with Resveratrol in the uterus of Sprague-Dawley rats
Description
Scholarly articles
Keywords
Research Subject Categories::MEDICINE , Cisplatin , Histology , Oxidative stress , Resveratrol , Sprague-Dawley rat , Research Subject Categories::MEDICINE
Citation
Okafor, I.A., Gbotolorun, S.C. (2018). Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats. Middle East Fertility Society Journal, 23(3), 205-210.