Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats

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dc.contributor.authorokafor, IA
dc.contributor.authorGbotolorun, SC
dc.date.accessioned2022-01-12T15:39:47Z
dc.date.available2022-01-12T15:39:47Z
dc.date.issued2018
dc.descriptionScholarly articlesen_US
dc.description.abstractBackground: Several studies have demonstrated Cisplatin-induced toxicity on the ovary. However, there is a dearth of literature on the effect of Cisplatin on the non-gravid uterus. Objective: This study investigated the effect of cisplatin and supplementation with Resveratrol on the oxidant status and histoarchitecture of the uterus in Sprague-Dawley rats. Materials and methods: Forty-five female Sprague–Dawley rats with average weight of 160 g divided into 9 groups (n = 5) were used in this study. Group 1 served as control and received distilled water. Groups 2 and 9 received cisplatin only. Groups 3, 4 and 5 received different doses (5, 10 and 20 mg/kg respectively) of Resveratrol after a single dose of cisplatin. Groups 6, 7 and 8 received different doses (5, 10 and 20 mg/ kg respectively) of Resveratrol before cisplatin. At sacrifice, the uterus was analysed for relative organ weight, histopathology and oxidation parameters. Result: No significant difference was observed in Glutathione (GSH), Superoxide dismutase (SOD) and Catalase (CAT) levels of rats treated with cisplatin and/or Resveratrol when compared to the control group (p < .05). Compared with the control group, Cisplatin treated groups showed a significant increase in Malondialdehyde (MDA) levels (p = .007 and .012) while groups treated with 20 mg/kg Resveratrol before cisplatin showed a significant decrease (p = .003) in their MDA levels. Cisplatin and Resveratrol treated groups showed normal histoarchitecture of the uterus. Conclusion: This study showed that cisplatin-induced oxidative stress can be prevented by supplementation with Resveratrol in the uterus of Sprague-Dawley ratsen_US
dc.identifier.citationOkafor, I.A., Gbotolorun, S.C. (2018). Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats. Middle East Fertility Society Journal, 23(3), 205-210.en_US
dc.identifier.issn1110-5690
dc.identifier.otherDOI:10.1016/j.mefs.2017.12.003
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10187
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.subjectCisplatinen_US
dc.subjectHistologyen_US
dc.subjectOxidative stressen_US
dc.subjectResveratrolen_US
dc.subjectSprague-Dawley raten_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleResveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley ratsen_US
dc.typeArticleen_US
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