Brine shrimp cytotoxicity and anti-mitotic activity of aqueous root-bark extract of securidaca longepedunculata (polygalaceae)

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dc.contributor.authorLawal, R.A
dc.contributor.authorLawal, S.K
dc.contributor.authorOdesanmi, O.S
dc.contributor.authorIsiaq, O.
dc.contributor.authorAdefisan, I.O
dc.contributor.authorBadmus, I.A
dc.contributor.authorYusuf, J.O
dc.contributor.authorEbuehi, O.A.T.
dc.date.accessioned2019-09-16T12:27:30Z
dc.date.available2019-09-16T12:27:30Z
dc.date.issued2018-03
dc.description.abstractSecuridaca longepedunculata is a savannah shrub found growing in South-West Nigeria and some other areas in Africa. It has been reported to be used in the treatment of over a hundred ailments. Its root bark is included in several anti-cancer decoctions in Nigeria. Despite its reported use as an anti-cancer plant, there is a dearth of information on the anti-cancer potential of Securidaca longepedunculata in Nigeria. The aim of this research is to determine the cytotoxic and anti-mitotic activity of aqueous root bark extract of Securidaca longepedunculata. Securidaca longepedunculata aqueous root-bark extract was prepared and used for the study. Cytotoxic activity of S. longepedunculata extract was determined by the brine shrimp toxicity assay and Allium cepa assay was used to assess the anti-mitotic activity. Brine shrimp toxicity assay showed an LC50 of 25.1 μg/mL and the Allium cepa assay revealed that 100 mg/mL extract caused a reduction in mitotic index (MI) which was comparable to that of the standard drug, methotrexate. Securidaca longepedunculata has potential as a cytotoxic agent.en_US
dc.identifier.citationLawal RA, Lawal SK, Odesanmi OS, Isiaq O, Adefisan IO, Badmus IA, Yusuf JO, Ebuehi OAT. Brine Shrimp Cytotoxicity and Anti-Mitotic Activity of Aqueous Root-Bark extract of Securidaca longepedunculata (Polygalaceae). Trop J Nat Prod Res. 2018; 2(3):109-113. doi.org/10.26538/tjnpr/v2i3.1en_US
dc.identifier.issn2616-0692
dc.identifier.issn2616-0684
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5549
dc.language.isoenen_US
dc.publisherTropical Journal of Natural Product Researchen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectAllium cepaen_US
dc.subjectBrine Shrimpen_US
dc.subjectSecuridaca longepedunculataen_US
dc.subjectCanceren_US
dc.subjectCytotoxicen_US
dc.subjectNigeriaen_US
dc.titleBrine shrimp cytotoxicity and anti-mitotic activity of aqueous root-bark extract of securidaca longepedunculata (polygalaceae)en_US
dc.typeArticleen_US
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