Pulmonary hypertension among 5 to 18 year old children with sickle cell anaemia in Nigeria

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dc.contributor.authorSokunbi, O.J.
dc.contributor.authorEkure, E.N.
dc.contributor.authorTemiye, E.O.
dc.contributor.authorAnyanwu, R.
dc.contributor.authorOkoromah, C.A.N.
dc.date.accessioned2019-11-12T10:31:41Z
dc.date.available2019-11-12T10:31:41Z
dc.date.issued2017-09-14
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground Pulmonary hypertension (PHT) is a significant cause of mortality in patients with sickle cell disease (SCD). Few studies on PHT in SCD have been carried out in children. This study aimed to estimate the prevalence of PHT in children with sickle cell anaemia (SCA) and determine its clinical and laboratory correlates. Methods In this cross sectional study, evaluation involved obtaining bio-data, history and physical examination findings in 175 SCA subjects with haemoglobin genotype SS aged 5 to 18years and 175 age and sex matched controls with haemoglobin genotype AA. PHT was determined using peak Tricuspid Regurgitant Velocity (TRV) obtained from echocardiography as a marker. Complete blood count (CBC), lactate dehydrogenase (LDH) assay, reticulocyte count, foetal haemoglobin (HbF) estimation as well as Human Immunodeficiency Virus (HIV) I and II, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) screening were done for patients with SCA. Results The mean peak TRV of subjects with SCA and controls was 2.2 ± 0.4 m/s and 1.9 ± 0.3 m/s respectively and prevalence of PHT among children with SCA and controls was 22.9% and 2.3% respectively. PHT in SCA correlated negatively with body mass index, haematocrit and haemoglobin. Conclusion This study affirms that PHT prevalence is high in children with SCA in Nigeria. Cardiovascular examination for signs of PHT is recommended for children with SCA and if required, further echocardiographic assessment from as early as five years.en_US
dc.identifier.citationSokunbi OJ, Ekure EN, Temiye EO, Anyanwu R, Okoromah CAN. Pulmonary hypertension among 5 to 18 year old children with sickle cell anaemia in Nigeria. PLoS One. 2017 Sep 14;12(9).en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6812
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectChildrenen_US
dc.subjectNigeriaen_US
dc.subjectSickle cell anaemiaen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titlePulmonary hypertension among 5 to 18 year old children with sickle cell anaemia in Nigeriaen_US
dc.typeArticleen_US
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