ALLELE FREQUENCIES AND HAPLOTYPE DIVERSITIES OF FIVE Y - CHROMOSOME SHORT TANDEM REPEAT LOCI IN A RANDOM SAMPLE OF YORUBA POPULATION IN LAGOS, NIGERIA

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dc.contributor.authorFakorede, S.T.
dc.contributor.authorAdekoya, K.O.
dc.contributor.authorAkpan, U.U.
dc.contributor.authorOgunlusi, O.V.
dc.date.accessioned2019-07-16T10:41:40Z
dc.date.available2019-07-16T10:41:40Z
dc.date.issued2019-08
dc.description.abstractY-chromosome short tandem repeats (Y-STRs) are specialized class of short tandem repeats located on human Y (male) chromosomes and are passed unchanged (barring a mutation) from one generation to the next. They are widely used in population genetic studies, forensics, paternity and genealogical DNA testing. The non-recombining nature of these loci makes them to have high discriminatory capacities among individuals of the same population or ethnicity. This is because they are polymorphic and exhibit high mutation rates. For Y-STR data to be applicable in forensics, knowledge of the haplotype frequencies in a geographic or ethnic substructure is required. DNA was extracted from peripheral blood sample of 110 unrelated Yoruba males, who have consented to participate in the research by signing the informed consent form, using conventional method. Five Y-STR markers (DYS392, DYS393, DYS449, DYS490 and DYS576) were typed and the PCR products were resolved on 4% agarose electrophoresis. Haplotype diversity was highest in DYS449 (0.840) and lowest in DYS392 (0.406). Also, the power of discrimination was found to be highest in DYS449 and lowest in DYS392 with 85.9% and 40.7%, respectively. The study revealed that the loci under study are suitable for use in identification, discrimination and forensic applications in the Yoruba population in Nigeria.en_US
dc.description.sponsorshipFederal University Wukari and Tetfund, Nigeriaen_US
dc.identifier.citationFakorede, Samson Taiwo, Adekoya, Khalid Olajide, Akpan, Utom-Obong Udom and Ogunlusi, Olajumoke Victoria (2019). Allele Frequencies and Haplotype Diversities of Five Y-Chromosome Short Tandem Repeat Loci in a Random Sample of Yoruba Population in Lagos, Nigeria. . FUW Trends in Science and Technology Journal. 4 (2) : 577 - 581.en_US
dc.identifier.issn24085162
dc.identifier.issnp-ISSN 20485170
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4337
dc.language.isoenen_US
dc.publisherFederal University Wukari, Nigeriaen_US
dc.subjectDiscriminationen_US
dc.subjectForensicsen_US
dc.subjectGenetic Diversityen_US
dc.subjectHaplotypesen_US
dc.subjectTandem Repeatsen_US
dc.subjectYorubaen_US
dc.titleALLELE FREQUENCIES AND HAPLOTYPE DIVERSITIES OF FIVE Y - CHROMOSOME SHORT TANDEM REPEAT LOCI IN A RANDOM SAMPLE OF YORUBA POPULATION IN LAGOS, NIGERIAen_US
dc.typeArticleen_US
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