Case Report on Hodgkin Lymphoma and Decompensated Chronic Liver Disease in a Patient With Chronic Hepatitis B Virus Infection: A Cause or an Effect?

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dc.contributor.authorBolarinwa, A.B
dc.contributor.authorAdebayo, L.A
dc.contributor.authorOtokiti, O
dc.contributor.authorOgbenna, A.A
dc.date.accessioned2022-01-13T10:47:37Z
dc.date.available2022-01-13T10:47:37Z
dc.date.issued2018
dc.descriptionScholarly articlesen_US
dc.description.abstractChronic hepatitis B infection has been associated with the development of non-Hodgkin lymphoma (NHL), but its role in the etiology of Hodgkin lymphoma (HL) has been sparsely reported. This case report highlights the possibility of hepatitis B infection playing a major role in the etiology of Hodgkin disease and the complexity of managing HL in the presence of a decompensated liver disease. The chemotherapy in a patient with Hodgkin lymphoma and a liver disease requires dose adjustment and may reactivate a latent hepatitis infection. Our patient is a 23-year-old male who presented with symptomatic anemia, multiple cervical lymphadenopathies, abnormal liver function, and chronic HBV infection. A histologic diagnosis of nodular sclerosing HL was made following an excisional biopsy. There was a progressive liver disease with bleeding from the gums, generalized petechial and ecchymotic rashes, thrombocytopenia, prolonged PT (INR >5), deepening jaundice, and markedly elevated bilirubin and liver enzymes. He had blood component support, and tenofovir 300 mg daily was initiated. Liver functions improved, but liver enzymes were still four times the upper limit of normal when chemotherapy was commenced. He had dose-adjusted ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy with gradual improvement in the liver function and resolution of lymphadenopathy. It is unclear whether HBV infection is a nidus for Hodgkin lymphoma in this patient as it is for non-Hodgkin lymphoma or if the progression of Hodgkin disease leads to the flare of this. The outcome in this patient also buttresses the fact that, with appropriate dose adjustment, chemotherapy can be administered in the settings of decompensated liver disease.en_US
dc.identifier.citationBolarinwa, A.B., Adebayo, L.A., Otokiti, O. and Ogbenna, A.A. (2018). Case Report on Hodgkin Lymphoma and Decompensated Chronic Liver Disease in a Patient With Chronic Hepatitis B Virus Infection: A Cause or an Effect? American Journal of Clinical Pathology, 150(1), S110en_US
dc.identifier.other10.1093/ajcp/aqy097.267
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10309
dc.language.isoenen_US
dc.publisherAmerican Journal of Clinical Pathologyen_US
dc.subjectChronic hepatitis Ben_US
dc.subjectInfectionen_US
dc.subjectLiver diseasesen_US
dc.subjectHepatitis infectionen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleCase Report on Hodgkin Lymphoma and Decompensated Chronic Liver Disease in a Patient With Chronic Hepatitis B Virus Infection: A Cause or an Effect?en_US
dc.typeArticleen_US
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