Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)
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Date
2011
Authors
Ajala, O.S.
Piggot, A.M.
Plisson, F.
Khalil, Z.
Huang, X.
Adesegun, S.A.
Coker, H.A.B.
Capon, R.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Tetrahedron Letters
Abstract
Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria,
led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridini um-indole-2-carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 lM)
against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of iki rydinium A and vinblastine is hypothesized
Description
Keywords
Indole alkaloids, Hunteria umbellata, Nigerian medicinal plant, Natural products chemistry.
Citation
APA