Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)
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Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridini um-indole-2-carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 lM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of iki rydinium A and vinblastine is hypothesized
Indole alkaloids, Hunteria umbellata, Nigerian medicinal plant, Natural products chemistry.