On artherogenic index of plasma in sickle cell anaemia patients

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dc.contributor.authorAkinbami, A.A
dc.contributor.authorUche, E.I
dc.contributor.authorSuleiman, A.M
dc.contributor.authorOgbenna, A.A
dc.contributor.authorOlowoselu, F.O
dc.contributor.authorAugustine, B
dc.contributor.authorBadiru, M.A
dc.contributor.authorBamiro, R.A
dc.contributor.authorKamson, O.R
dc.date.accessioned2022-07-28T12:13:00Z
dc.date.available2022-07-28T12:13:00Z
dc.date.issued2019
dc.descriptionScholarly articleen_US
dc.description.abstractIntroduction: Sickle cell anaemia (SCA) is an inherited abnormality of haemoglobin associated with reduced life expectancy. Patients' complications include dyslipideamia. This study was aimed at determining the artherogenic index of plasma (AIP) in sickle cell anaemia patients and compares the value to HbAA controls value. A high AIP is strongly predictive of elevated cardiovascular risk. Methods: A comparative study was conducted among SCA patients attending the haematology clinic, Lagos State University Teaching Hospital (LASUTH) and HbAA Phenotype controls. A total of 304 participants were recruited consisting of equal numbers of SCA and HbAA controls. Single lipid profiles were done; logarithms of triglycerides/high density lipoprotein were calculated to obtain AIP and lipid profile ratios established for all participants. Results: There were lower mean values of Total Cholesterol (TC), High Density Lipoprotein(HDL) and Low Density Lipoprotein (LDL) amongst SCD participants than controls and higher mean values of triglycerides (TG) and Very Low Density Lipoprotein (VLDL) in SCD p < 0.05. The AIP in SCD ranges from -0.62 to 1.32 while that of controls ranges from -0.56 to 0.61.The mean AIP were 0.14 ± 0.29 and -0.009 ± 0.26 in SCD and controls respectively. P value = 0.002. Conclusion: AIP value is higher in sickle cell anaemia than controls, the former have lower mean values of TC, HDL and LDL and higher mean values of TG and VLDL.en_US
dc.identifier.citationAkinbami, A.A., Uche, E.I., Suleiman, A.M., Ogbenna, A.A., Olowoselu, F.O., Augustine, B., Badiru, M.A., Bamiro, R.A. and Kamson, O.R. (2019). On artherogenic index of plasma in sickle cell anaemia patients. PanAfrican medical journal, 32.en_US
dc.identifier.issn1937 - 8688
dc.identifier.other10.11604/pamj.2019.32.141.17166
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10931
dc.language.isoenen_US
dc.publisherPanAfrican medical journalen_US
dc.subjectArtherogernic index of plasmaen_US
dc.subjectLipid profileen_US
dc.subjectSickle cell diseaseen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleOn artherogenic index of plasma in sickle cell anaemia patientsen_US
dc.typeArticleen_US
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