Genetics of Childhood Steroid Sensitive Nephrotic Syndrome: An Update

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dc.contributor.authorLane, B.M.
dc.contributor.authorCason, R.
dc.contributor.authorEsezobor, C.I.
dc.contributor.authorGbadegesin, R.A.
dc.date.accessioned2020-02-11T14:01:18Z
dc.date.available2020-02-11T14:01:18Z
dc.date.issued2019
dc.description.abstractAdvances in genome science in the last 20 years have led to the discovery of over 50 single gene causes and genetic risk loci for steroid resistant nephrotic syndrome (SRNS). Despite these advances, the genetic architecture of childhood steroid sensitive nephrotic syndrome (SSNS) remains poorly understood due in large part to the varying clinical course of SSNS over time. Recent exome and genome wide association studies from well-defined cohorts of children with SSNS identified variants in multiple MHC class II molecules such as HLA-DQA1 and HLA-DQB1 as risk factors for SSNS, thus stressing the central role of adaptive immunity in the pathogenesis of SSNS. However, evidence suggests that unknown second hit risk loci outside of the MHC locus and environmental factors also make significant contributions to disease. In this review, we examine what is currently known about the genetics of SSNS, the implications of recent findings on our understanding of pathogenesis of SSNS, and how we can utilize these results and findings from future studies to improve the management of children with nephrotic syndrome.en_US
dc.identifier.citationLane, B.M.; Cason R.; Esezobor, C.I.; Gbadegesin, R.A. Genetics of Childhood Steroid Sensitive Nephrotic Syndrome: An Update (2019). Front Pediatr. 2019;7:8. doi: 10.3389/fped.2019.00008. eCollection 2019.en_US
dc.identifier.otherdoi: 10.3389/fped.2019.00008.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7633
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.subjectNephrotic syndromeen_US
dc.subjectSSNSen_US
dc.subjectPodocyteen_US
dc.subjectMHC class II locusen_US
dc.subjectHLA DQ/DRen_US
dc.titleGenetics of Childhood Steroid Sensitive Nephrotic Syndrome: An Updateen_US
dc.typeArticleen_US
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