The immune system cell populations were increased in salt-induced hypertensive rats without an increase in the serum testosterone level

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dc.contributor.authorAwobajo, F.O.
dc.contributor.authorOkafor, A.E.
dc.contributor.authorAdebayo, H.O.
dc.date.accessioned2020-07-02T13:28:48Z
dc.date.available2020-07-02T13:28:48Z
dc.date.issued2018
dc.description.abstractThe consumption of dietary salt has significantly increased globally, especially in the developed countries. High dietary salt intake has been linked to onset and complications in hypertension with a dimorphism tendency. There is scanty information about the influence of high salt diet on the immune cell population and androgen level in circulation. Male Sprague–Dawley rats of 8 weeks old were used for this study. They were divided into control (fed 0.1% salted feed) and salt-loaded groups (fed 8% salted feed) for 8 weeks. All experimental rats were allowed access to clean drinking water; daily feed consumption was measured in addition to weekly weight. On confirmation of hypertension using PowerLab® data acquisitions system, the rats were sacrificed and blood samples were collected into EDTA and sterile sample bottles. EDTA-blood samples were used for white blood cell and CD4 counts while the serum was used for hormonal assays. All salt-loaded rats became hypertensive, with a significant increase in total white blood cell, lymphocyte, neutrophil, monocyte, and CD4 cell counts. However, the eosinophil count was significantly decreased in salt-loaded rats. This study showed no change in the serum testosterone in salt-loaded male rats compared with control. In summary, dietary salt loading while precipitating hypertension also activated increased production of white blood cells and CD4 cells without any change in the serum testosterone level.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8443
dc.publisherPhysiology Internationalen_US
dc.subjectDietary salten_US
dc.subjectImmunityen_US
dc.subjectDifferential white blood cellen_US
dc.subjectLymphocytesen_US
dc.subjectCD4en_US
dc.subjectSprague–Dawley ratsen_US
dc.titleThe immune system cell populations were increased in salt-induced hypertensive rats without an increase in the serum testosterone levelen_US
dc.typeArticleen_US
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