Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine

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dc.contributor.authorTagbo, Beckie N
dc.contributor.authorBancroft, Rowan E
dc.contributor.authorFajolu, Iretiola
dc.contributor.authorAbdulkadir, Mohammed B
dc.contributor.authorBashir, Muhammad F
dc.contributor.authorOkunola, Olusola P
dc.contributor.authorIsiaka, Ayodeji H
dc.contributor.authorLawal, Namadi M
dc.contributor.authorEdelu, Benedict O
dc.contributor.authorOnyejiaka, Ngozi
dc.contributor.authorIhuoma, Chinonyerem J
dc.contributor.authorNdu, Florence
dc.contributor.authorOzumba, Uchenna C
dc.contributor.authorOgunsola, Folasade
dc.contributor.authorSaka, Aishat O
dc.contributor.authorFadeyi, Abayomi
dc.contributor.authorAderibigbe, Sunday A
dc.contributor.authorAbdulraheem, Jimoh
dc.contributor.authorYusuf, Adamu G
dc.contributor.authorNdow, Peter S
dc.contributor.authorOgbogu, Philomena
dc.contributor.authorKanu, Chinomnso
dc.contributor.authorEmina, Velly
dc.contributor.authorMakinwa, Olajumoke J
dc.contributor.authorGehre, Florian
dc.contributor.authorYusuf, Kabir
dc.contributor.authorBraka, Fiona
dc.contributor.authorMwenda, Jason M
dc.contributor.authorTicha, Johnson M
dc.contributor.authorNwodo, Dorothy
dc.contributor.authorWorwui, Archibald
dc.contributor.authorBiey, Joseph N
dc.contributor.authorKwambana-Adams, Brenda A
dc.contributor.authorAntonio, Martin
dc.contributor.authorfor the African Paediatric Bacterial Meningitis Surveillance Network
dc.date.accessioned2019-10-24T09:42:50Z
dc.date.available2019-10-24T09:42:50Z
dc.date.issued2019
dc.description.abstractBackground Historically, Nigeria has experienced large bacterial meningitis outbreaks with high mortality in children. Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae are major causes of this invasive disease. In collaboration with the World Health Organization, we conducted longitudinal surveillance in sentinel hospitals within Nigeria to establish the burden of pediatric bacterial meningitis (PBM). Methods From 2010 to 2016, cerebrospinal fluid was collected from children <5 years of age, admitted to 5 sentinel hospitals in 5 Nigerian states. Microbiological and latex agglutination techniques were performed to detect the presence of pneumococcus, meningococcus, and H. influenzae. Species-specific polymerase chain reaction and serotyping/grouping were conducted to determine specific causative agents of PBM. Results A total of 5134 children with suspected meningitis were enrolled at the participating hospitals; of these 153 (2.9%) were confirmed PBM cases. The mortality rate for those infected was 15.0% (23/153). The dominant pathogen was pneumococcus (46.4%: 71/153) followed by meningococcus (34.6%: 53/153) and H. influenzae (19.0%: 29/153). Nearly half the pneumococcal meningitis cases successfully serotyped (46.4%: 13/28) were caused by serotypes that are included in the 10-valent pneumococcal conjugate vaccine. The most prevalent meningococcal and H. influenzae strains were serogroup W and serotype b, respectively. Conclusions Vaccine-type bacterial meningitis continues to be common among children <5 years in Nigeria. Challenges with vaccine introduction and coverage may explain some of these finding. Continued surveillance is needed to determine the distribution of serotypes/groups of meningeal pathogens across Nigeria and help inform and sustain vaccination policies in the country.en_US
dc.identifier.citationBeckie N Tagbo, Rowan E Bancroft, Iretiola Fajolu, Mohammed B Abdulkadir, Muhammad F Bashir, Olusola P Okunola, Ayodeji H Isiaka, Namadi M Lawal, Benedict O Edelu, Ngozi Onyejiaka, Chinonyerem J Ihuoma, Florence Ndu, Uchenna C Ozumba, Frances Udeinya, Folasade Ogunsola, Aishat O Saka, Abayomi Fadeyi, Sunday A Aderibigbe, Jimoh Abdulraheem, Adamu G Yusuf, Peter Sylvanus Ndow, Philomena Ogbogu, Chinomnso Kanu, Velly Emina, Olajumoke J Makinwa, Florian Gehre, Kabir Yusuf, Fiona Braka, Jason M Mwenda, Johnson M Ticha, Dorothy Nwodo, Archibald Worwui, Joseph N Biey, Brenda A Kwambana-Adams, Martin Antonio for the African Paediatric Bacterial Meningitis Surveillance Network. Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine, Clinical Infectious Diseases, Volume 69, Issue Supplement_3, 1 October 2019, Pages S81–S88,en_US
dc.identifier.urihttps://doi.org/10.1093/cid/ciz474
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6467
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectpediatric, meningitis, Nigeria, neumococcus, meningococcusen_US
dc.titlePediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccineen_US
dc.typeArticleen_US
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