Predictors of pregnancy in microbicide trials

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dc.contributor.authorHalpern, V.
dc.contributor.authorLie, C.
dc.contributor.authorFeldblum, P.
dc.contributor.authorDamme, L.V.
dc.contributor.authorMauck, M.W.C.
dc.contributor.authorGuedou, F.
dc.contributor.authorMirembe, F.
dc.contributor.authorGovinden, R.
dc.contributor.authorObunge, O.
dc.contributor.authorOgunsola, F.T.
dc.date.accessioned2020-01-22T15:23:18Z
dc.date.available2020-01-22T15:23:18Z
dc.date.issued2010-08-25
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: High pregnancy rates undermine the conduct and interpretation of HIV prevention trials. We performed this analysis to identify baseline participant characteristics associated with increased risk of pregnancy in recent vaginal microbicide trials. Study Design: We analyzed the data from four recently completed Phase III trials of candidate microbicides for prevention of HIV infection. Cox proportional hazard models, stratified by site nested within study, were used to determine the baseline factors that predict pregnancy. Six thousand seven hundred forty-eight women contributed data for this analysis. Results: Pregnancies were detected in a total of 1826 (27.1%) women. The hazard of pregnancy was higher for women who had a history of pregnancy, were living with a man or reported more sexual acts not protected by condoms in the week prior to enrollment. The risk of pregnancy was lower in older participants; in women with more years of education; in women who reported more sexual partners at baseline interview; in women who reported using intrauterine contraception, implants, sterilization or injectables and in women who reported use of a condom during their last act of vaginal intercourse. Conclusions: Our data suggest that current use or acceptance of intrauterine contraception, implants, sterilization or injectables is the most effective approach to reduce pregnancy rates and might be a useful eligibility criterion in future HIV prevention trials.en_US
dc.identifier.citationHalpern, V, Lie, C, Feldblum, P, Damme L.V, and the Microbicide Research Group; Mauck, M.W.C, Guédou, F, Mirembe, F, Govinden, R, Obunge, O. and Ogunsola, F. (2011). Predictors of pregnancy in microbicide trials, Contraception, 83:436–440.en_US
dc.identifier.urihttps://www.google.com/search?q=Predictors+of+pregnancy+in+microbicide+trials&oq=Predictors+of+pregnancy+in+microbicide+trials&aqs=chrome..69i57j69i60j69i61l2.842j0j7&sourceid=chrome&ie=UTF-8
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7482
dc.language.isoenen_US
dc.subjectMicrobicideen_US
dc.subjectHIV prevention trialsen_US
dc.subjectPregnancyen_US
dc.subjectRisk factorsen_US
dc.subjectContraceptionen_US
dc.subjectResearch Subject Categories::SOCIAL SCIENCES::Social sciences::Educationen_US
dc.titlePredictors of pregnancy in microbicide trialsen_US
dc.typeArticleen_US
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