Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder

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dc.contributor.authorAfolabi, B.B.
dc.contributor.authorOladipo, O.O.
dc.contributor.authorAkanmu, A.S.
dc.contributor.authorAbudu, O.O.
dc.contributor.authorSofola, O.A.
dc.contributor.authorBroughton Pipkin, F.
dc.date.accessioned2020-09-09T14:47:23Z
dc.date.available2020-09-09T14:47:23Z
dc.date.issued2016-07
dc.description.abstractSickle cell disease (haemoglobin SS (HbSS)) mainly affects those of West African origin and is associated with hypervolaemia. Plasma volume rises by up to 50% in normal pregnancy but was previously found to be paradoxically contracted in late sickle cell pregnancy. The renin-angiotensin-aldosterone system is activated very early in human pregnancy to support the plasma volume expansion. We hypothesised that activation of the renin-angiotensin-aldosterone system would be blunted in pregnant women with sickle cell disease.en_US
dc.identifier.citationAfolabi BB, Oladipo OO, Akanmu AS, Abudu OO, Sofola OA, Broughton Pipkin F. Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder. J Renin Angiotensin Aldosterone Syst. 2016 Jul;17(3). doi: 10.1177/1470320316670444. Print 2016 Jul. PubMed PMID: 27678389; PubMed Central PMCID: PMC5843859.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8822
dc.language.isoenen_US
dc.publisherJ Renin Angiotensin Aldosterone Systen_US
dc.subjectSickle cell diseaseen_US
dc.subjectplasma volumeen_US
dc.subjectPregnancyen_US
dc.subjectrenin–angiotensin–aldosterone system (RAAS)en_US
dc.subjectsickle cell anaemiaen_US
dc.subjectvolume regulatory hormonesen_US
dc.titleVolume regulatory hormones and plasma volume in pregnant women with sickle cell disorderen_US
dc.typeArticleen_US
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