Microwave-Assisted Solvent-Free Arylation of Amino acids with Halogenobenzenes
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Date
2018-06-21
Authors
Sowole, M.A.
Adebisi, A.B.
Olasupo, I.A.
Izunobi, J.U.
Familoni, O.B.
Journal Title
Journal ISSN
Volume Title
Publisher
Chemical Society of Nigeria
Abstract
The solventless microwave-assisted arylation and heteroarylation of different aliphatic and cyclic amino acids 2a–e were carried out on activated, substituted o-nitrohalogenobenzenes 1a–h and 2-chloro-3-nitropyridine 1i, in the presence of potassium carbonate and potassium fluoride for 0.5 h at 70 W, to give substituted N-(o-nitrophenyl)amino-2-carboxylic acid 3–16 and N-(m-nitropyridyl)amino-2-carboxylic acid 17–18 adducts in yields ranging from 5–98% .
Description
Keywords
amino acids, arylation, halogenobenzenes, microwave synthesis