Short-Term and Long-Term Effects of Low and High Fat Diets on Lipid Profile and Acetylcholinesterase Activity in Different Brain Regions of Male Wistar Rats

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dc.contributor.authorEbuehi, O.A.T.
dc.contributor.authorAdewolu, Abiodun
dc.date.accessioned2024-05-08T12:10:53Z
dc.date.available2024-05-08T12:10:53Z
dc.date.issued2020
dc.descriptionScholarly article
dc.description.abstractHigh intake of saturated fat and cholesterol has been related to an increase risk of cardiovascular disease. Given their important role in neuronal function, there has been an increasing focus on altered lipid levels in brain disorder. In this study, the brain lipid profiles and acetylcholinesterase activity in 30 Wistar rats administered with low (8% lard, 1.3% cholesterol) and high (16% lard, 2.5% cholesterol) fat diets for two and four weeks were determined. High density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triacylglycerol (TAG) and low density lipoprotein cholesterol (LDL-C) levels were determined using commercial diagnostic kits, while the activity of acetylcholinesterase was determined by Ellman’s method. High fat diet (HFD) causes a significant decrease in high density lipoprotein cholesterol (HDL-C) in the plasma at both weeks when compared with the control (p<0.05). Total cholesterol (TC), triacylglycerol (TAG) and low density lipoprotein cholesterol (LDL-C) were significantly increase in the plasma of the experimental rats at four weeks when compared with the control (p<0.05). Significant increase was observed in HDL-C, TC, TAG and HDL-C in olfactory lobe, cerebellum and medulla oblongata at four weeks when compared with the control (p<0.05), while a significant decrease was observed in the cerebra lipid profile when compared with the control (p<0.05). Low fat and high fat diets cause a significant increase in the activity of acetylcholinesterase in olfactory lobe, cerebrum, cerebellum and medulla oblongata at four weeks when compared with the control group (p<0.05). In conclusion, consumption of high dietary fat in this study alters brain lipid profile, and decrease brain acetylcholine level, therefore may contribute to progressive cognitive impairment.
dc.identifier.citationEbuehi, O.A.T., and Adewolu, Abiodun(2020). Short-Term and Long-Term Effects of Low and High Fat Diets on Lipid Profile and Acetylcholinesterase Activity in Different Brain Regions of Male Wistar Rats . ARC Journal of Neuroscience, 5 (1): 1-9.
dc.identifier.issn2456-057X
dc.identifier.other10.20431
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/12865
dc.language.isoen
dc.publisherARC Journal of Neuroscience
dc.relation.ispartofseriesARC Journal of Neuroscience; 5(1)
dc.titleShort-Term and Long-Term Effects of Low and High Fat Diets on Lipid Profile and Acetylcholinesterase Activity in Different Brain Regions of Male Wistar Rats
dc.typeArticle
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