A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver

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dc.contributor.authorEbuehi, Osaretin A.T.
dc.contributor.authorErukainure, Ochuko L.
dc.contributor.authorAdione, Rebecca
dc.contributor.authorOyenihi, Ayodeji B.
dc.date.accessioned2019-09-27T07:36:30Z
dc.date.available2019-09-27T07:36:30Z
dc.date.issued2018-02-02
dc.description.abstractA novel herbal beverage (HB) was formulated from blends of Moringa oleifera, Dennettia tripetala, and Citrus sinensis and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (p < 0.05) reversed after treatment with HB. Treatment with HB led to significant (p < 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (p < 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.en_US
dc.identifier.citationEbuehi, Osaretin & Erukainure, Ochuko & Adione, Rebecca & Oyenihi, Ayodeji. (2018). A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver. Comparative Clinical Pathology. 10.1007/s00580-018-2654-0.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6208
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectAntioxidanten_US
dc.subjectCrude oilen_US
dc.subjectHerbal beverageen_US
dc.subjectOxidative injuryen_US
dc.titleA novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liveren_US
dc.typeArticleen_US
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