Nigella sativa (black seed) oil ameliorates CCl4-induced hepatotoxicity and mediates neurotransmitter levels in male Sprague Dawley albino rats.
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Date
2019
Authors
Ebuehi, O.A.T.
Olowojaiye, J.
Ajagun-Ogunleye, M.O.
Erukainure, O.L.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Food Biochemistry
Abstract
The liver is a metabolically active organ which is prone to oxidative damage. The
hepatoprotective effect of Nigella sativa (black seed oil extract) on carbon tetrachlo ride (CCl4)-induced hepatotoxicity in Sprague-Dawley albino rats was determined.
There were four groups of eight rats; Group 1 (control) was administered with dis tilled water for 28 days, Group 2 was administered with 4 ml/kg of CCl4 (70% olive
oil: 30% CCl4) on alternate days for 28 days. Group 3 was administered with 4 ml/kg
of CCl4 (70% olive oil: 30% CCl4) and 2 ml/kg of Nigella sativa oil orally for 28 days.
Group 4 was administered with 4 ml/kg of CCl4 (70% Olive oil: 30% CCl4) and 4 ml/kg
of Nigella sativa oil orally for 28 days. Blood samples were collected for biochemi cal assessment. Liver, kidney, and brain tissues were determined for antioxidant en zymes and histopathological features. There were significant ameliorative effects of
the oil extract in the treatment groups compared to control (p < .05).
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Scholarly article
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Citation
Ebuehi, O.A.T, Olowojaiye, J, Ajagun-Ogunleye, M.O,Erukainure, O.L(2019). Nigella sativa (black seed) oil ameliorates CCl4-induced hepatotoxicity and mediates neurotransmitter levels in male Sprague Dawley albino rats. Journal of Food Biochemistry, 43 (10): 1-10.