Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition

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dc.contributor.authorAlaribe, S.C.
dc.contributor.authorEsposito, T.
dc.contributor.authorSansone, F.
dc.contributor.authorAdesegun, S.
dc.contributor.authorPagano, I.
dc.contributor.authorPiccinelli, A.L.
dc.contributor.authorCelano, R.
dc.contributor.authorCuesta Rubio, O.
dc.contributor.authorCoker, H.A.
dc.contributor.authorNabavi, S.M.
dc.contributor.authorRastrelli, L.
dc.contributor.authorPicerno, P.
dc.date.accessioned2022-09-13T07:45:16Z
dc.date.available2022-09-13T07:45:16Z
dc.date.issued2019-11-08
dc.descriptionScholarly articleen_US
dc.description.abstractPropolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against a-amylase and a-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.en_US
dc.description.sponsorshipThis study was financially supported by the University of Lagos, Nigeria grant (CRC No: M2012/02)en_US
dc.identifier.citationAlaribe, C. S., Esposito, T., Sansone, F., Sunday, A., Pagano, I., Piccinelli, A. L., Celano, R., Cuesta Rubio, O., Coker, H. A., Nabavi, S. M., Rastrelli, L., & Picerno, P. (2021). Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition. Natural product research, 35(18), 3095–3099. https://doi.org/10.1080/14786419.2019.1682576en_US
dc.identifier.issnDOI: 10.1080/14786419.2019.1682576
dc.identifier.issnhttps://doi.org/10.1080/14786419.2019.1682576
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11460
dc.language.isoenen_US
dc.publisherNatural Product Research Formerly Natural Product Lettersen_US
dc.relation.ispartofserieshttps://doi.org/10.1080/14786419.2019.1682576;
dc.subjectNigerian propolisen_US
dc.subjectpolyphenolsen_US
dc.subjectfree-radical scavenging activityen_US
dc.subjecta-amylase and a-glucosidase enzymesen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleNigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibitionen_US
dc.typeArticleen_US
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