Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition
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Cuesta Rubio, O.
Natural Product Research Formerly Natural Product Letters
Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against a-amylase and a-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.
Nigerian propolis , polyphenols , free-radical scavenging activity , a-amylase and a-glucosidase enzymes , Research Subject Categories::PHARMACY
Alaribe, C. S., Esposito, T., Sansone, F., Sunday, A., Pagano, I., Piccinelli, A. L., Celano, R., Cuesta Rubio, O., Coker, H. A., Nabavi, S. M., Rastrelli, L., & Picerno, P. (2021). Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition. Natural product research, 35(18), 3095–3099. https://doi.org/10.1080/14786419.2019.1682576