Seroprevalence of cytomegalovirus antibodies amongst normal pregnant women in Nigeria

Simple item page
dc.contributor.authorAkinbami, A.A
dc.contributor.authorRabiu, K.A
dc.contributor.authorAdewunmi, A.A
dc.contributor.authorWright, K.O
dc.contributor.authorDosunmu, A.O
dc.contributor.authorAdeyemo, T.A
dc.contributor.authorAdediran, A
dc.contributor.authorOsunkalu, V.O
dc.date.accessioned2019-09-10T13:06:50Z
dc.date.available2019-09-10T13:06:50Z
dc.date.issued2011-12-16
dc.description.abstractObjective Cytomegalovirus (CMV), a ubiquitous virus belonging to the herpes family, is known to be transmitted frequently to developing fetuses in pregnancy. In an immunocompromised state like pregnancy, primary infection through blood transfusion or reactivation of a latent CMV infection can cause severe illness. The study was carried out to determine the seroprevalence of the immunoglobulin G (IgG) antibody to cytomegalovirus amongst pregnant women in correlation with previous exposure to blood transfusion. Methods A cross sectional study was carried out amongst 179 HIV negative pregnant women attending the antenatal clinic of Lagos State University Teaching Hospital (LASUTH), Ikeja, Nigeria. Five mL of blood was collected and stored in a plain bottle, centrifuged on the same day and the serum stored at −20°C. All samples were screened for anti-CMV IgG antibodies using the enzyme linked immunosorbent assay (ELISA). Consenting participants were instructed to fill a semi-structured questionnaire to obtain demographic and other related information. Statistical analysis of the results was done using Pearson’s chi squared test for analytical assessment. Results A total of 97.2% of the pregnant women recruited for this study were anti-CMV IgG positive. Out of the 179 recruited for the study 174 responded to the question on previous history of blood transfusion, 14.9% of the respondents (26 of 174) had a previous history of blood transfusion and all tested positive to the anti-CMVIgG antibody. However, past history of blood transfusion and educational level were found to be insignificant to the risk of acquiring CMV infection. Conclusion The seroprevalence of the CMV antibody amongst pregnant women in this environment is high in relation to findings in other developing countries. There is the need to assess anti-CMV immunoglobulin M antibodies in pregnant women, which is a determinant of active infection. Keywords: CMV, IgG, pregnant womenen_US
dc.identifier.citationAkinbami, A. A., Rabiu, K. A., Adewunmi, A. A., Wright, K. O., Dosunmu, A. O., Adeyemo, T. A., ... & Osunkalu, V. O. (2011). Seroprevalence of cytomegalovirus antibodies amongst normal pregnant women in Nigeria. International journal of women's health, 3, 423.en_US
dc.identifier.otherdoi: 10.2147/IJWH.S24850
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5470
dc.language.isoenen_US
dc.publisherDovepress - International Journal of Womens Healthen_US
dc.subjectCMV, IgG, pregnant womenen_US
dc.titleSeroprevalence of cytomegalovirus antibodies amongst normal pregnant women in Nigeriaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijwh-MAIN ARTICLE.pdf
Size:
132.79 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Haematology and Blood Transfusion- Scholarly Publications