Synthesis and in-vitro antibacterial study of some Schiff base copper (II) complexes derived from 4-phenylsemicarbazone
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Date
2016-09-03
Authors
Fasina, T. M.
Dueke-eze, C. U.
Ejiah, F. N.
Ebesunun, B. E.
Oluwalana, E. A.
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Abstract
Six new Schiff base ligands derived from the condensation of 5-substituted 2-hydroxybenzaldehyde with 4-phenylsemicarbazide (HL1-HL6) and their copper (II) complexes were synthesized and characterized using melting point, 1 H NMR and Infrared (IR). IR data confirmed that the ligands coordinated to the metal ion in a bidentate manner through the azomethine nitrogen and carbonyl oxygen resulting in metal complexes with a 1: 2 metal: ligand ratio. The Schiff bases and copper complexes exhibited good in-vitro antibacterial activity against S. aureus and E. coli in ethyl acetate with zones of inhibition ranging from 9-27 mm indicating their potential as good broad spectrum antibacterial agents.
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Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry , Copper(II) Schiff bases, 4-phenylsemicarbazide, in-vitro, antibacterial screening
Citation
Fasina, T. M., Dueke-Eze, C. U., Elijah, F. N., Ebesunun, B. E., & Oluwalana, E. A. (2016). Synthesis and in-vitro antibacterial study of some Schiff base copper (II) complexes derived from 4-phenylsemicarbazone. NISEB Journal, 16(3), 118-124