Homocysteine and folate levels as indicators of cerebrovascular accident

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dc.contributor.authorOsunkalu, VO.
dc.contributor.authorOnajole, AT.
dc.contributor.authorOdeyemi, KA.
dc.contributor.authorOgunnowo, BA.
dc.contributor.authorSekoni, AO.
dc.contributor.authorAyoola, GA.
dc.contributor.authorAdediran, A.
dc.contributor.authorAkinde, OR.
dc.contributor.authorAdeyemo, AT.
dc.date.accessioned2020-11-24T10:20:21Z
dc.date.available2020-11-24T10:20:21Z
dc.date.issued2010
dc.descriptionStaff Publicationsen_US
dc.description.abstractBackground: Homocysteinemia has been established as a risk factor for cardiovascular disorders by the American Heart Association.1 Cerebrovascular accident (stroke) is presently ranked as one of the leading causes of morbidity and mortality worldwide. The aim of this study was to determine homocysteine and folate levels and some basic hematologic parameters in patients who sustain a cerebrovascular accident and those who do not. Methodology: In total, 100 participants were recruited, comprising 40 clinically diagnosed stroke (hemorrhagic or thromboembolic) patients and 60 healthy control subjects. Plasma homocysteine and folate levels were measured. Anticoagulated whole blood samples were evaluated for hemoglobin concentration (Hb), packed cell volume (PCV), white blood cell (WBC) count, and mean cell volume (MCV). Results: The mean age of stroke patients was 62 ± 12 years and that of controls was 55 ± 18 years (P = 0.1756). Mean plasma homocysteine levels for stroke patients and controls were 17.7 ± 4.4 µmol/L and 9.5 ± 2.4 µmol/L, respectively (P = 0.0000) and mean plasma folate levels for the groups were 6.5 ± 2.9 µg/dL and 4.0 ± 2.4 µg/dL (P = 0.0407). The MCV for stroke patients was significantly higher than that for controls (85 fl versus 82 fl, P = 0.04). Mean homocysteine levels correlated inversely with Hb and PCV (r = −0.08 and r = −0.122, respectively) and weakly with WBC (P = 0.125). Conclusion: Homocysteinemia is a major predictor of cerebrovascular accident in the black Nigerian population.en_US
dc.identifier.citationOsunkalu VO, Onajole AT, Odeyemi KA, Ogunnowo BA, Sekoni AO, Ayoola GA, Adediran A, Akinde OR, TA Adeyemo (2010). Homocysteine and folate levels as indicators of cerebrovascular accident. Journal of blood medicine 1:131–134.en_US
dc.identifier.issn2076-6270
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8993
dc.language.isoenen_US
dc.publisherJournal of blood medicineen_US
dc.subjecthomocysteinemiaen_US
dc.subjectfolateen_US
dc.subjectcerebrovascular accidenten_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleHomocysteine and folate levels as indicators of cerebrovascular accidenten_US
dc.typeArticleen_US
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