Biomarkers of toxicity in Clarias gariepinus exposed to sublethal concentrations of polycyclic aromatic hydrocarbons

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dc.contributor.authorSogbanmu, Temitope O.
dc.contributor.authorOsibona, Adesola O.
dc.contributor.authorOguntunde, Olubanji A.
dc.contributor.authorOtitoloju, Adebayo A.
dc.date.accessioned2019-02-08T08:52:21Z
dc.date.available2019-02-08T08:52:21Z
dc.date.issued2018-08
dc.description.abstractPhysiological, biochemical and histological indices in Clarias gariepinus broodstock, and teratogenic indices in embryos exposed to sublethal concentrations of naphthalene, phenanthrene and pyrene were investigated in 2014 using a static-renewal bioassay protocol. Phenanthrene (1.41 mg l−1) was the most toxic, followed by pyrene (1.53 mg l−1) and naphthalene (7.21 mg l−1), based on 96 h LC50 values. Hepatosomatic indices were significantly higher in naphthalene- and pyrene-treated males compared with solvent controls, whereas fecundity in females was significantly lower by factors of 2.4 (naphthalene), 2.8 (phenanthrene) and 2.4 (pyrene), compared with controls. Catalase levels were lower in female phenanthrene-treated fish compared with controls. Histological alterations observed in PAH-treated fish include oedema, inflammatory cells, epithelial lifting and hyperplasia in the gills, vacuolation, haemosiderin pigments and sinusoidal congestion in the liver, and degenerated zona radiata in the ovary. Teratogenic effects were not observed, as evidenced by the lack of histological alterations in embryos spawned from pre-exposed broodstock. Sex-specific responses and the utility of biomarkers at cellular and individual levels of organisation are therefore demonstrated for holistic evaluations of polycyclic aromatic hydrocarbons in ecotoxicological studies.en_US
dc.identifier.citationSogbanmu, T. O., Osibona, A. O., Oguntunde, O. A, and Otitoloju, A. A. (2018). Biomarkers of toxicity in Clarias gariepinus exposed to sublethal concentrations of polycyclic aromatic hydrocarbons. African Journal of Aquatic Science 43(3): 281-292en_US
dc.identifier.issn1608-5914
dc.identifier.otherhttps://doi.org/10.2989/16085914.2018.1491825
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/3658
dc.language.isoenen_US
dc.publisherAfrican Journal of Aquatic Scienceen_US
dc.subjectAfrican sharptooth catfishen_US
dc.subjectBiochemical indicesen_US
dc.subjectBiological responsesen_US
dc.subjectHistological alterationsen_US
dc.subjectNaphthaleneen_US
dc.subjectPhenanthreneen_US
dc.subjectPhysiological indicesen_US
dc.subjectPyreneen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCESen_US
dc.titleBiomarkers of toxicity in Clarias gariepinus exposed to sublethal concentrations of polycyclic aromatic hydrocarbonsen_US
dc.typeArticleen_US
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