Effects of Ascorbic Acid Intake on the Intima-Media Thickness and Blood Flow Velocities of the Carotid Artery in Patients With Sickle Cell Anemia

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dc.contributor.authorOlowoyeye, Omodele
dc.contributor.authorJaja, SI
dc.contributor.authorKehinde, MO
dc.contributor.authorAwosanya, GO
dc.contributor.authorIrurhe, NK
dc.contributor.authorAdeyomoye, AA
dc.contributor.authorSoyebi, KO
dc.contributor.authorArogundade, RA
dc.contributor.authorAdekunle, OM
dc.contributor.authorSoneye, BK
dc.contributor.authorTubi, OO
dc.date.accessioned2019-11-02T15:05:06Z
dc.date.available2019-11-02T15:05:06Z
dc.date.issued2011
dc.description.abstractThis study aims to investigate and compare the effects of six-week oral vitamin C supplementation on blood velocities, intima-media thickness, and cross-sectional diameter (CSD) of the common carotid artery of sickle cell anemia (SCA) and non–sickle cell anemia (NSCA) subjects using sonography. Results showed that the CSD and end-diastolic velocity were significantly higher (P < .002 and P < .001, respectively) in the SCA subjects than in the NSCA subjects in the presupplementation phase. Calculated resistivity index (RI) was significantly lower in the SCA subjects (P < .003). Vitamin C supplementation had a slight effect on all the measured parameters in the NSCA subjects but caused a significant increase in peak systolic velocity (PSV) (P < .02) and RI (P < .01) in SCA. A comparison of change in each measured variable between the groups showed significant differences. Oral supplementation with vitamin C should be encouraged in patients with SCA as prophylaxis against endothelial damage, thereby preventing vaso-occlusive crises and their associated morbidity.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6703
dc.subjectsickle cell anemia, intima-media thickness, carotid artery, vitamin C, end-diastolic velocityen_US
dc.titleEffects of Ascorbic Acid Intake on the Intima-Media Thickness and Blood Flow Velocities of the Carotid Artery in Patients With Sickle Cell Anemiaen_US
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