Effects of Ascorbic Acid Intake on the Intima-Media Thickness and Blood Flow Velocities of the Carotid Artery in Patients With Sickle Cell Anemia

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Olowoyeye, Omodele
Jaja, SI
Kehinde, MO
Awosanya, GO
Irurhe, NK
Adeyomoye, AA
Soyebi, KO
Arogundade, RA
Adekunle, OM
Soneye, BK
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This study aims to investigate and compare the effects of six-week oral vitamin C supplementation on blood velocities, intima-media thickness, and cross-sectional diameter (CSD) of the common carotid artery of sickle cell anemia (SCA) and non–sickle cell anemia (NSCA) subjects using sonography. Results showed that the CSD and end-diastolic velocity were significantly higher (P < .002 and P < .001, respectively) in the SCA subjects than in the NSCA subjects in the presupplementation phase. Calculated resistivity index (RI) was significantly lower in the SCA subjects (P < .003). Vitamin C supplementation had a slight effect on all the measured parameters in the NSCA subjects but caused a significant increase in peak systolic velocity (PSV) (P < .02) and RI (P < .01) in SCA. A comparison of change in each measured variable between the groups showed significant differences. Oral supplementation with vitamin C should be encouraged in patients with SCA as prophylaxis against endothelial damage, thereby preventing vaso-occlusive crises and their associated morbidity.
sickle cell anemia, intima-media thickness, carotid artery, vitamin C, end-diastolic velocity