Changes in Serum Cortisol, Thyroid Hormones and Lipid Profiles in Nigerian Men and Women on 1st and 2nd Line Antiretroviral Therapy for 52 Weeks
No Thumbnail Available
Date
2015
Authors
Ebuehi, O.A.T.
Awolola, A.
Akanmu, A.S.
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Virology and Molecular Biology
Abstract
BACKGROUND: Human immunodeficiency syndrome (HIV) which affects the whole body can interfere with proper endocrine function, and hormones in turn can affect the disease progression. Cortisol suppresses many aspect of the immune response, including proliferation of lymphocytes, the activity of natural killer cells, macrophages and neutrophils, and the production of certain cytokines. Acquired immunodeficiency syndromes (AIDS) is associated with reduced thyroid hormone production.
OBJECTIVE: The study is to determine the changes in cortisol, thyroid hormones and lipid profiles of Nigerian men and women on first and second line highly active antiretroviral therapy (HAART) for 52 weeks.
METHODS: The serum concentration of cortisol, thyroid stimulating hormones(TSH), thyroxine(T4) and triiodothyronine(T3) and the lipids (HDL, Total cholesterol and triacyl glycerol) profiles were determined in 40 HAART positive on 1st line, 40 HAART positive on 2nd line, 40 HIV positive HAART naive and compared to 40 HIV negative controls. RESULTS: Serum concentrations of cortisol were significantly (p<0.05) increased in the patients on both HIV positive HAART experience of 1st and 2nd line and naïve subjects compared to the negative control. There was a significant decrease in the free-thyroxine (FT4) in the HIV positive group (HAART experienced and naïve) compared to the HIV negative control group. There was no significant difference in the thyrotropin (TSH) and the free triiodothyronine (FT3) in all the three HIV positive group compared to the HIV negative control group. No significant differences were observed in renal and lipid profiles in all the different groups. CONCLUSIONS: Data of the study indicate that serum levels of cortisol and thyroid hormones may be used as baseline periodic markers during antiretroviral therapy, though subtle imbalances may have a major impact on the quality of life and many people with HIV may benefit from supplementation if appropriate.
Description
Scholarly article
Keywords
Citation
Ebuehi, O.A.T., Awolola, A., Akanmu, A.S. (2015). Changes in Serum Cortisol, Thyroid Hormones and Lipid Profiles in Nigerian Men and Women on 1st and 2nd Line Antiretroviral Therapy for 52 Weeks. International Journal of Virology and Molecular Biology 4(1): 12-18.