In vivo analyses of the effects of co-administration of Carica papaya leaf extract with ciprofloxacin

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dc.contributor.authorImaga, N.O.A.
dc.contributor.authorUkpo, G.E.
dc.contributor.authorOwolabi, M.A.
dc.contributor.authorShekoni, A.I.
dc.contributor.authorGbenle, G.O.
dc.date.accessioned2019-09-20T15:06:02Z
dc.date.available2019-09-20T15:06:02Z
dc.date.issued2012-12-29
dc.description.abstractCarica papaya leaf extract is an antisickling phytomedicine reported to inhibit the polymerisation of defective hemoglobin S molecules in sickle cell individuals. In this research, the biochemical effects of ciprofloxacin, a wide spectrum antibiotic, co-administered with C. papaya leaf extract was studied. Using standard methods for biochemical, hematological and antioxidant assays, results showed that ciprofloxacin administration gave rise to increase in oxidative stress markers, which lowered considerably during co-administration with C. papaya leaf extract, whereas administration of C. papaya leaf extract alone did not produce any of such side-effects. Co-administration of both drugs was found to have no deleterious effects on body organs and erythrocytes. This suggests that the presence of C. papaya leaf extract had a palliative effect on the free radicals produced during ciprofloxacin administration.en_US
dc.identifier.citationImaga NOA, Ukpo, G.E., Owolabi, M.A, Shekoni AI., Gbenle G. O. African Journal of Pharmacy and Pharmacology 6(48). 3268-3273. 2012en_US
dc.identifier.issn1996-0816
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5889
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectCarica papayaen_US
dc.subjectantisickling agentsen_US
dc.subjectantibioticsen_US
dc.subjectantioxidantsen_US
dc.titleIn vivo analyses of the effects of co-administration of Carica papaya leaf extract with ciprofloxacinen_US
dc.typeArticleen_US
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