Haemoglobin oxygen saturation, leucocyte count and lactate dehydrogenase are predictors of elevated cerebral blood flow velocity in Nigerian children with sickle cell anaemia

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dc.contributor.authorOjewunmi, Oyesola Oyewole
dc.contributor.authorAdeyemo, Titilope Adenike
dc.contributor.authorOsuntoki, Akinniyi Adediran
dc.contributor.authorImaga, Ngozi Awa
dc.contributor.authorOyetunji, Ajoke Idayat
dc.date.accessioned2019-09-20T15:07:24Z
dc.date.available2019-09-20T15:07:24Z
dc.date.issued2017
dc.description.abstractBackground: Transcranial Doppler ultrasound (TCD) scan, which measures blood flow velocity through the time-averaged mean of maximum velocities (TAMMVs) in the internal carotid arteries and middle cerebral arteries, is a useful screening tool for predicting stroke risk in children with sickle cell anaemia (SCA). Aim: To investigate which clinical and laboratory indices predict abnormal TCD velocity in children with SCA. Methods: Fifty-four SCA patients with normal TCD (TAMMV < 170 cm/s), classified as negative TCD (NTCD), and 93 patients with conditional and abnormal TCD velocities (TAMMV ≥ 170 cm/s) classified as positive TCD were recruited. The haemoglobin oxygen saturation, haematological variables, nitric oxide metabolites and lactate dehydrogenase activity of the patients were analysed. Results: The mean (SD) age was 7.16 (3.84) years (range 2–16). The median SpO2 of the patients in the positive TCD group was significantly lower than that of the negative TCD group (p = 0.002). Multivariate logistic regression analysis indicated that the MCV [odds ratio (OR) 1.12, 95% confidence interval (CI) 1.04–1.22, p = 0.01)], MCH (OR 1.34, 95% CI 1.02–1.77, p = 0.04), leucocyte count (OR 1.26, 95% CI 1.07–1.49, p = 0.01) and lactate dehydrogenase (LDH) level (OR 1.00, 95% CI 1.00–1.01, p = 0.01) were independent predictors of high cerebral blood flow velocities. Conclusions: These clinical and laboratory indices are characteristic of chronic hypoxia and severe anaemia and are predictors of abnormal cerebral blood flow velocity. They can be used to predict stroke risk in children with SCA when access to TCD screening is limited.en_US
dc.identifier.citationOyesola Oyewole Ojewunmi, Titilope Adenike Adeyemo, Akinniyi Adediran Osuntoki, Ngozi Awa Imaga & Ajoke Idayat Oyetunji (2018) Paediatrics and International Child Health, 38:1:34-39.en_US
dc.identifier.issn2046-9047
dc.identifier.issn2046-9055
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5894
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectTranscranial Doppleren_US
dc.subjecthaemoglobin oxygen saturationen_US
dc.subjectcerebral blood flow velocityen_US
dc.subjectSickle cell anaemiaen_US
dc.subjectstroke risken_US
dc.subjectlactate dehydrogenaseen_US
dc.subjectlaboratory predictorsen_US
dc.subjectNigeriaen_US
dc.titleHaemoglobin oxygen saturation, leucocyte count and lactate dehydrogenase are predictors of elevated cerebral blood flow velocity in Nigerian children with sickle cell anaemiaen_US
dc.typeArticleen_US
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