Comparative Studies of Genotoxicity and Anti-plasmodial Activities of Stem and Leaf Extracts of Alstonia boonei (De Wild) in Malaria-infected Mice.

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dc.contributor.authorBabamale, O. A.
dc.contributor.authorIyiola, O. A.
dc.contributor.authorAdeyemi, S. B.
dc.contributor.authorSulaiman, A. F.
dc.contributor.authorAbdulkareem, A. O.
dc.contributor.authorAnifowoshe, A. T.
dc.contributor.authorAwe, O. D.
dc.contributor.authorAjani, D.
dc.contributor.authorUgbomoiko, U. S.
dc.date.accessioned2017-10-13T09:03:34Z
dc.date.available2017-10-13T09:03:34Z
dc.date.issued2017-09
dc.descriptionStaff Publicationen_US
dc.description.abstractDrug resistance in malaria infection is a serious public health challenge. Thus, scientific search for alternative treatment measures among the local medicinal plants is exigent. We therefore investigated the anti-plasmodial efficacy and genotoxicity of the methanolic leaf and stem extracts of Alstonia plant at varying concentration (200 mg/kg, 400 mg/kg and 600 mg/kg) in mice infected with chloroquine sensitive Plasmodium berghei. The phytochemical screening of the extract revealed that leaf sample contained significantly higher secondary metabolites, except saponins (p<0.05). Anti-plasmodial activities of the two extracts were duration and dose- dependent. Stem bark extract showed higher curative potential with inhibition rate of 56.71% at 400 mg/kg whereas, leaf extract was efficient at 600mg/kg with 52.15% inhibition rate. Stem bark extract at 400 mg/kg improved the enzymatic activities of the mice; it lowered serum ALT (6.88±4.42) and increased liver ALT (41.07±5.56). Similarly, 400 mg/kg leaf extract showed highest AST (70.65±4.00) and ALT (44.65±7.83) activities in the kidney and liver respectively. Analysis of genotoxicity revealed that micronucleus and abnormal (binucleated, notched and blebbed) were prevalent among the experimental mice which increased significantly (p<0.05) at all concentrations except at 600mg/kg leaf extract. Therefore, this present study indicates that both leaf and stem bark extracts of A. boonei possess anti-plasmodial activity and are less genotoxic when compared with standard drug.en_US
dc.identifier.citationBabamale, O. A. and et al (2017), Comparative Studies of Genotoxicity and Anti-plasmodial Activities of Stem and Leaf Extracts of Alstonia boonei (De Wild) in Malaria-infected Mice. Nigerian Journal of Parasitology; Volume 38(2).en_US
dc.identifier.issn1117 4145
dc.identifier.uriwww.researchgate.net/publication/319525908
dc.identifier.urihttps://www.ajol.info/index.php/njpar/article/view/161656
dc.identifier.urihttps://www.unilorin.edu.ng › Faculty of Life Sciences
dc.identifier.urihttp://ir.unilag.edu.ng:8080/xmlui/handle/123456789/2196
dc.language.isoenen_US
dc.relation.ispartofseriesStaff Publication;
dc.subjectGenotoxicityen_US
dc.subjectPlasmodium berghei;en_US
dc.subjectMetabolitesen_US
dc.subjectMicronucleusen_US
dc.subjectBlebbeden_US
dc.subjectStandard drugen_US
dc.titleComparative Studies of Genotoxicity and Anti-plasmodial Activities of Stem and Leaf Extracts of Alstonia boonei (De Wild) in Malaria-infected Mice.en_US
dc.typeArticleen_US
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