Antisickling property of Carica papaya leaf extract

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dc.contributor.authorImaga, N.O.A.
dc.contributor.authorGbenle, G.O.
dc.contributor.authorOkochi, V.I.
dc.contributor.authorAkanbi, S.O.
dc.contributor.authorEdeoghon, S.O.
dc.contributor.authorOigbochie, V.
dc.contributor.authorKehinde, M.O.
dc.contributor.authorBamiro, S.B.
dc.date.accessioned2019-09-20T15:02:03Z
dc.date.available2019-09-20T15:02:03Z
dc.date.issued2009-04
dc.description.abstractSickle cell disease (SCD) results from a mutation in the hemoglobin inside the red blood cells, where a glutamic acid at position 6 is replaced by a valine. Many phytomedicines have been identified as potential antisickling agents, stemming from reported usage as ethnomedicines by the local folk. This research examined methanolic leaf extracts of Carica papaya L. (Caricaceae) for possible in vitro antisickling and membrane-stabilizing activities involving the use of positive (p-hydroxybenzoic acid 5 mg/ml) and negative (normal saline) controls for the antisickling experiments and osmotic fragility test on Hbss red blood cells obtained from non-crisis state sickle cell patients. Fragiliograms indicated that the plant extract reduced hemolysis and protected erythrocyte membrane integrity under osmotic stress conditions. Pretreatment of SS cell suspensions with C. papaya leaf extract inhibited formation of sickle cells under severe hypoxia, with only 0 - 5% sickle cells at 40 min compared with untreated SS cell suspensions which had over 60% sickle cells. These results indicate the feasibility of C. papaya as an attractive potential candidate for SCD therapy.en_US
dc.identifier.citationImaga, N. O. A, Gbenle, G. O., Okochi, V. I., Akanbi S. O., Edeoghon, S.O., Oigbochie, V. , Kehinde, M. O. and Bamiro, S.B. African J. of Biochemistry Research 4(4) 102-106. 2009en_US
dc.identifier.issn1996-0778
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5881
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectAntisicklingen_US
dc.subjectmembrane-stabilizingen_US
dc.subjectsickle cell diseaseen_US
dc.subjecterythrocyte fragilityen_US
dc.subjectCarica papayaen_US
dc.subjecttoxicity profileen_US
dc.titleAntisickling property of Carica papaya leaf extracten_US
dc.typeArticleen_US
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