Anti-diabetic and hypoglycemic properties of fibre-enriched cake in alloxan-induced diabetic rats.
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Date
2013
Authors
Erukainure, O.L.
Ebuehi, O.A.T.
Adeboyejo, F.O.
Okafor, E.N.
Hafizur, R.M.
Elemo, G.N
Journal Title
Journal ISSN
Volume Title
Publisher
Mediterranean Journal of Nutrition and Metabolism
Abstract
Studies have provided evidence of the hypoglycemic
properties of fiber-containing foods compared to
fiber-free foods. In this study, the hypoglycemic properties
and beneficial effects of fiber-enriched cake in alloxaninduced
diabetic rats were reported. Diabetes was induced
by a single intraperitoneal injection of alloxan. Fiberenriched
cake was produced from selected fruits and fed to
the treatment group. The rats were monitored daily for food
intake, and body weight. Their blood glucose levels were
monitored on weekly basis. Treatment lasted for 14 days,
after which the rats were sacrificed by cervical dislocation.
Blood was collected by cardiac puncture and centrifuged to
obtain serum which was analyzed to evaluate serum insulin
level. Histological study was carried out on the pancreatic
tissues. There was no significant difference in diet intake
and body weight among the experimental groups. Feeding
on the formulated cake led to 68.75 % reduction of
the blood glucose level compared to the diabetic group. Significant increase (p\0.05) in serum insulin level was
observed in the cake-fed group. Feeding on the formulated
cake led to restoration of pancreatic b-cells. The fiberenriched
cake had a therapeutic protective effect against
diabetes which can serve as a functional food in the
treatment and management of the disease.
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Scholarly article
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Citation
Erukainure, O.L., Ebuehi, O.A.T., Adeboyejo, F.O., Okafor, E.N., Hafizur, R.M., Elemo, G.N(2013).Anti-diabetic and hypoglycemic properties of fibre-enriched cake in alloxan-induced diabetic rats. Mediterranean Journal of Nutrition and Metabolism 6(2):135-141.