Effect of sertraline and thioridazine on the metabolism of 5-hydroxy tryptamine in rabbit brain, liver and heart.
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Date
2004
Authors
Ebuehi, O.A.T.
Sanya, A.O.
Lewis, O.A.
Journal Title
Journal ISSN
Volume Title
Publisher
African Scientist
Abstract
The effect of sertraline and thioridazine on the metabolism of 5-hydroxy tryptamine in rabbit brain, liver and heart were investigated. 5ml of 0.5mg/kg sertraline or 5ml of 0.5mg/kg thioridazine or 5ml of 0.89% NaCl/kg were orally administered to rabbits for 30 days. The rabbits were sacrificed by decapitation, after starving them overnight, their brains, livers and hearts were quickly excised. Brain, liver and heart protein and serotonin concentrations and monoamine oxidase activities were determined.
Results indicate that sertraline and thioridazine potentiated protein and serotonin in the brain, liver and heart, but had no significant effect on monoamine oxidase activity. Data of the study suggest that sertraline and thioridazine may alter some neutral functions mediated by serotoninergic neurotransmission.
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Scholarly article
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Citation
Ebuehi, O.A.T., Sanya, A.O.,Lewis, O.A.(2004). Effect of sertraline and thioridazine on the metabolism of 5-hydroxy tryptamine in rabbit brain, liver and heart. African Scientist . 5(1): 21-26.