Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital

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dc.contributor.authorOsegbe, I.D
dc.contributor.authorSoriyan, O.O
dc.contributor.authorOgbenna, A.A
dc.contributor.authorOkpara, H.C
dc.contributor.authorAzinge, E.C
dc.date.accessioned2022-10-12T09:27:39Z
dc.date.available2022-10-12T09:27:39Z
dc.date.issued2016
dc.descriptionScholarly articleen_US
dc.description.abstractIntroduction: cardiovascular risk factors are prevalent in HIV-positive patients which places them at increased risk for cardiovascular disease (CVD). We aimed to determine the risk factors and risk assessment for CVD in HIV-positive patients with and without antiretroviral therapy. Methods: this was a cross-sectional study of HIV-positive patients attending the Lagos University Teaching Hospital, Nigeria. Anthropometric and blood pressure measurements were performed; fasting lipid profile, plasma glucose, homocysteine and hsCRP were determined, as well as prevalences and risk assessments. Statistical tests were used to compare the groups and p-value <0.05 was considered to be significant. Results: 283 subjects were recruited for this study (100 HIV-positive treatment-naive, 100 HIV-positive treated and 83 HIV negative controls). Compared to the controls, mean (sd) values were significantly higher among HIV-treated subjects: waist circumference=88.7 (10.4), p=0.035; systolic bp= 124.9 (20.7), p=0.014; glucose= 5.54 (1.7), p=0.015; triglyceride= 2.0 (1.2), p<0.001; homocysteine= 10.9 (8.9-16.2), p=0.0003; while hsCRP= 2.9 (1.4-11.6), p=0.002 and HDL-C=0.9 (0.4), p=<0.0001 were higher among the HIV-naïve subjects. Likewise, higher prevalences of the risk factors were noted among the HIV-treated subjects except low HDL-C (p<0.001) and hsCRP (p=0.03) which were higher in the HIV￾naïve group. Risk assessment using ratios showed high risk for CVD especially in the HIV-naïve group. The median range for Framingham risk assessment was 1.0 - 7.5%. Conclusion: Risk factors and risk assessment for CVD are increased in HIV-positive patients with and without antiretroviral therapy.Routine evaluation and risk assessment for CVD irrespective of therapy status is necessary to prevent future cardiovascular events.en_US
dc.identifier.citationOsegbe, I. D., Soriyan, O. O., Ogbenna, A. A., Okpara, H. C., & Azinge, E. C. (2016). Risk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospital. The Pan African medical journal, 23, 206. https://doi.org/10.11604/pamj.2016.23.206.7041en_US
dc.identifier.issn1937-8688
dc.identifier.other10.11604/pamj.2016.23.206.7041
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11734
dc.language.isoenen_US
dc.publisherPanAfrican medical journalen_US
dc.subjectAtherosclerosisen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectHIVen_US
dc.subjectRisk assessmenten_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleRisk factors and assessment for cardiovascular disease among HIV-positive patients attending a Nigerian tertiary hospitalen_US
dc.typeArticleen_US
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