Ameloblastic carcinoma: a multicenter Nigerian study.
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Date
2010-09-01
Authors
Ndukwe, K.C.
Adebiyi, E.K.
Ugboko, V.I.
Ladeinde, A.L.
Okojie, V.N.
Ajike, S.O.
Olasoji, H.O.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
PURPOSE:
To obtain a national profile on the prevalence and management of ameloblastic carcinoma in Nigerians.
MATERIALS AND METHODS:
Data were collected from the case files of patients with a histologic diagnosis of ameloblastic carcinoma from 4 tertiary referral centers in Nigeria from January 1980 to December 2008.
RESULTS:
Twenty patients were seen within the study period. There were 11 male and 9 female patients, with a male-to-female ratio of 1.2:1. Their ages ranged from 16 to 85 years (mean +/- SD, 41.63 +/- 19.8 years). The duration of the lesion before presentation was 6 months to 4 years. Twelve cases occurred in the posterior mandible alone, 1 case occurred in the anterior mandible alone, and 4 cases involved the anterior and posterior mandible. The posterior part of the maxilla was involved in 3 cases. A majority of the cases (17) occurred de novo, and 3 patients presented with carcinoma ex-ameloblastoma. Treatment included surgical resection with or without neck dissection. Eight patients declined treatment after diagnosis. Surgery was planned for 12 patients, but 2 patients died of intractable bleeding episodes before surgery. Mandibulectomies and maxillectomies were performed for 10 patients. Follow-up was carried out for 5 patients. Recurrence ranged from 6 to 96 months after the first surgery. Overall deaths recorded involved 6 patients. Three patients died within 3 years after the initial surgery and 1 patient died about 8 years after the initial surgery. One patient is still alive and well 1 year after surgery.
CONCLUSION:
Ameloblastic carcinoma is an uncommon malignancy. Most cases occur in the mandible and arise de novo. Early diagnosis and radical local excision remain the mainstay of treatment.
Description
Keywords
Ameloblastic carcinoma , Nigerians
Citation
Ndukwe KC, Adebiyi EK, Ugboko VI, Adeyemo WL, Ajayi FO, Ladeinde AL, Okojie VN, Ajike SO, Olasoji HO. Ameloblastic carcinoma: a multicenter Nigerian study. J Oral Maxillofac Surg. 2010 Sep;68(9):2111-4.