Genetics and genomics etiology of nonsyndromic orofacial clefts
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Orofacial clefts (OFC) are complex birth defects. Seventy percent of all clefts are classified as nonsyndromic, where no recognizable structural defects other than cleft are seen. The remaining 30% are syndromic, where a cleft presents with a consistently defined structural anomaly; these are usually Mendelian in nature. Studies using contemporary genomic techniques, bioinformatics, and statistical analyses have led to appreciable advances in identifying the causes of syndromic forms of clefts. Meanwhile, only modest progress has been recorded for nonsyndromic clefts. This commentary gives an overview of the important cleft gene discoveries found using various genomic methods and tools. At the end we discuss the discoveries’ value for genetic counseling and as foundations for future research.
Genetics , Genomics , Orofacial clefts , Research Subject Categories::ODONTOLOGY
Adeyemo, W.L. and Butali, A. (2017). Genetics and genomics etiology of nonsyndromic orofacial clefts. Mol Gen Gen Med, Vol.1(1).